tlc

The Boiling Point of Cannabis’ Complexity

THC or Delta-9-Tetrahydrocannabinol is a cannabinoid that many are familiar with since this has been the primary focus of conversations and research pertaining to cannabis for years. In recent times, however, we have started to discover that what makes cannabis so incredible isn’t just this one cannabinoid. In fact, it isn’t even the many combinations of different cannabinoids that are possible but in reality, something much more complex.
The reason that cannabis is as effective as it is for a plethora of different ailments and offers such a wide range of benefits, flavors, and aromas, is due to a combination of cannabinoids, terpenes, flavonoids, and other compounds found in the cannabis plant. Simply lighting a joint of a random strain of cannabis, however, will not provide the full effects possible.

What You Need to Know About Getting the Most Out of Your Herb

Terpenes matter as much as cannabinoids. This cannot be expressed enough. Terpenes which are also found in fruits, vegetables, and other plants are essential to the overall effects of cannabis. Terpenes also provide a plethora of different health benefits as well. Therefore, many cannabis consumers and patients alike have started to pay more attention to the terpene profiles present in the products they purchase.
Here are some of the common terpenes found in cannabis strains along with their potential medical benefits. While this is nowhere near a comprehensive list as there are over 125 terpenes found in cannabis, these are the most common and abundant.

  • ß-myrcene: Analgesic. Anti-inflammatory, Antibiotic, Antimutagenic
  • ß-caryophyllene: Anti-inflammatory, Cytoprotective (gastric mucosa), Antimalarial
  • d-limonene: Cannabinoid agonist, Immune potentiator, Antidepressant, Antimutagenic
  • linalool: Sedative, Antidepressant, Anxiolytic, Immune potentiator
  • pulegone: Memory booster, AChE inhibitor, Sedative, Antipyretic
  • 1,8-cineole (eucalyptol): AChE inhibitor, Increases cerebral, blood flow, Stimulant, Antibiotic, Antiviral, Anti-inflammatory, Antinociceptive
  • a-pinene: Anti-inflammatory, Bronchodilator, Stimulant, Antibiotic, Antineoplastic, AChE inhibitor
  • a-terpineol: Sedative, Antibiotic, AChE inhibitor, Antioxidant, Antimalarial
  • terpineol-4-ol: AChE inhibitor. Antibiotic
  • p-cymene: Antibiotic, Anticandidal, AChE inhibitor

Unfortunately, while many of these terpenes are present in various cannabis strains, their benefits are often abolished through a process known as pyrolytic destruction. This process is where terpenes are heated to a higher temperature than their boiling point therefore essentially eliminating them from existence. The same thing occurs when cannabinoids are heated beyond their boiling points. Here are the boiling points for the most common cannabinoids and terpenes found in cannabis.

Common Cannabinoid Boiling Points

  • Delta-9-tetrahydrocannabinol (THC): 157˚C / 315˚F
  • Cannabidiol (CBD): 160-180˚C / 320-356˚F
  • Cannabinol (CBN): 185˚C / 365˚F
  • Cannabichromene (CBC): 220˚C / 428˚F
  • Cannabigerol (CBG): 220˚C/428˚F
  • Delta-8-tetrahydrocannabinol (Delta-8-THC): 175-178˚C / 347-352.4˚F
  • Tetrahydrocannabivarin (THCV): < 220˚C / <428˚F

Common Terpene Boiling Points

  • ß-myrcene: 166-168˚C / 330.8-334.4˚F
  • ß-caryophyllene: 119˚C / 246.2˚F
  • d-limonene: 177˚C / 350.6˚F
  • linalool: 198˚C / 388.4˚F
  • pulegone: 224˚C / 435.2˚F
  • 1,8-cineole (eucalyptol): 176˚C / 348.8˚F
  • a-pinene: 156˚C / 312.8˚F
  • a-terpineol: 217-218˚C / 422.6-424.4˚F
  • terpineol-4-ol: 209˚C / 408.2˚F
  • p-cymene: 177˚C / 350.6˚F

Pyrolytic Destruction – Ruining Your Cannabis One Boiling Point at a Time

As you can see, the boiling points of various terpenes and cannabinoids drastically vary. To avoid pyrolytic destruction many consumers and patients have turned to vaporizing cannabis products. This is because vaporizing eliminates the combustion required for smoking dry herb. Vaporizers, however, tend to heat to specific degrees only; therefore only a portion of the terpenes and cannabinoids are absorbed by the consumer.
While vaporizing would allow a consumer to pinpoint and consume products at a certain temperature allowing them to better tailor their consumption towards the effects they are after, in the process the boiling points of many other terpenes and cannabinoids are not reached or are surpassed. So essentially vaporizing still does not allow consumers and patients to truly experience the full potential of the effects of different cannabis products.

A Complete Cannabis Consumption Experience

One company, however, is aiming to change that. NWT Holdings, the parent company of Firefly vaporizers, has introduced a new vaporizer product that utilizes dynamic convection heating. This process of heating cannabis products is different than what is utilized by other vaporizers on the market today.
Dynamic convection heating gradually heats the chamber around your cannabis across an extensive temperature range. This allows the consumer to benefit from each individual terpene and cannabinoid being heated to their exact boiling point over the course of a 7 second inhale.
This is incredible for both consumers and patients alike. In fact, this could revolutionize the way that we consume cannabis. Never has anyone been able to truly experience the full potential of cannabis but now thanks to innovative leaders and products such as the new line from Firefly featuring dynamic convection heating, we can. This will not only enhance the benefits that we receive as consumers but will also allow us to learn more about the many cannabis strains available on the market today.
 

cbd oil

3 Things to Look For When Buying CBD Oil

CBD oil, e-juice, and other products are becoming increasingly popular as the medicinal properties of cannabis become more and more mainstream. But unfortunately, the dubious legal status of marijuana in the U.S. and around the world means that regulation of these products is inconsistent at best.
There are many companies jumping on the medical marijuana bandwagon right now, taking advantage of the lack of oversight to sell you cheap, poor quality products – some of which could even be dangerous to your health.
So how can consumers today tell the good stuff from the bad? Research, of course. Before you purchase CBD oil, or any other cannabis product, you should do your homework. Always read product labels carefully, and check out the manufacturers’ website.
Here are the 3 most important things to look for, to ensure that what you’re about to buy is safe, healthy and of the highest quality:

3 Signs of High Quality CBD Oil

1. Check the Source

The best products always start with the best ingredients, and quality CBD oil starts with the soil.
Most CBD products are made from industrial hemp, which is what’s called a hyperaccumulator. Basically, that means that it can grow even in contaminated soil, absorbing heavy metals and other toxins through the roots. This makes it useful for phytoremediation (a.k.a. “soil cleanup”). But it also means that it’s possible for hemp to contain toxic levels of zinc, lead, mercury, arsenic, etc.
So it’s very important to know where your CBD oil sources it’s hemp before you consume it. Look for hemp grown in the U.S. or Canada (where there is strict state regulation), using organic farming methods if possible.
Also note whether the product is made from CBD-isolate (a.k.a. “pure CBD”). These products contain only cannabidiol, and none of the other active plant compounds. Look for “whole plant” or “full spectrum” products instead, as these contain other cannabinoids (CBN, CBL, terpenes, etc.) which interact with the CBD to increase it’s medicinal effects.

2. Extraction Method

Another important thing to consider is the extraction method, or how the CBD oil was derived from the plant. Some manufacturers use chemical solvents like butane, propane or hexane to extract their product. Oils produced in this way can contain dangerous carcinogens (a.k.a. substances known to cause cancer). Avoid these products at all costs.
Ethanol extraction is a somewhat safer method, which results in a cleaner product and higher concentrations of CBD and other cannabinoids.
But the gold standard is what’s called “supercritical CO2 extraction,” a method that uses carbon dioxide gas under extreme cold and pressure. This requires more expensive equipment – which of course generally means a more expensive product – but it results in the cleanest, safest, and highest quality CBD oil on the market.

3. Independently Tested

Perhaps the most important thing of all to look for is product that has been inspected and tested by an independent laboratory. After all, manufacturers are out to make money, and many of them will make false claims if it will help them sell more product.
Only buy CBD oil from a manufacturer whose claims have been tested and verified by an impartial 3rd party lab. And don’t be satisfied with a simple seal on the label! Go online to the seller’s website to find out exactly where their product was tested. If you really want to be sure, request a “Certificate of Analysis”. If such a certificate is not available, then you’d best find another supplier.
As laws continue to shift in favor of hemp and medical marijuana, increased regulation and oversight will improve the safety and quality of all cannabis products on the market. But for the time being, it’s up to us to be smart consumers, to educate and protect ourselves.
Knowledge is power, after all.

brainaging

Cannabinoids Slow Down Brain Aging

How Do Cannabinoids Keeps the Brain from Slowing Down?

A German study found that brains of older mice benefited from cannabinoids. The main chemical tested is known as THC (tetrahydrocannabinol). The gains were incredibly significant because the minds of older mice were on par with the minds of other younger mice who were abstained from cannabis.
THC was tested on several mice from different ages for two months. The tests were all repeated daily. The tests included navigating through a water maze and recognizing familiar objects. Younger mice on THC struggled to accomplish their tasks, but the older mice showed better brain performance.

How Do Older Mice Benefit from THC?

The biochemical pathway of older mice grows less active over time, but science has shown that THC causes their brain’s biochemical pathways to grow more active. The results are astonishing because a low dose of THC was all that was needed to engage these biochemical pathways.
The mice did not seem to experience the effects normally associated with consuming THC though. The older mice on small amounts of THC could accomplish their tasks as well or better than younger mice who were THC free. This has big implications to how we approach human testing in the future.

What Are University Scientists Hoping to Accomplish with Their Findings?

Researchers from the Hebrew University and the University of Bonn plan on starting human trials by the end of the year. Human testing will be similar to the mouse studies and explore the ramifications of various levels of use. Basically, humans of varying ages will be tested with familiar tasks on a daily basis to see if they get worse at them.
This is just the first phase of testing. The hope is that the older human brain can be regenerated by at least five years to a decade without the use or need of extra invasive care. We are still a long way from receiving cannabis treatments for things like Alzheimer’s and other forms of dementia but this is an important step in the right direction.

cancer marijuana

Cancer Treatments: Now With Marijuana

Marijuana is an old remedy.

Modern cancer patients aren’t the only people to understand the healing power of marijuana. Marijuana is the name given to the cannabis plant during 20th century prohibition. Cannabis grows wild in warm and tropical climates throughout the world and has been cultivated commercially for eons. Prohibition has given cannabis many other aliases as people developed code. Names like pot, grass, cannabis, weed, hemp, hash, hydro, ganja, and dozens of others all describe the same plant.
Records show marijuana has been used in herbal remedies dating back to the Chin Dynasty in China. Ancient doctors could see the effects of using cannabis as well as today and prescribed it for many maladies. The herb was so powerful that even the Romans put it in their medical texts.
Scientists have identified many biologically active components in marijuana that are the main reason it is so useful medically. These compounds are called cannabinoids. The two most studied of the hundred or so cannabinoids are delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD). Other cannabinoids are being studied but haven’t had the same amount of press or research put into them.

Is marijuana a legal treatment?

cancer treatmentAt this time, the US Drug Enforcement Administration (DEA) lists marijuana and cannabinoids as Schedule I controlled substances that cannot legally be prescribed, possessed, or sold under federal law. Whole or crude marijuana (including marijuana oil or hemp oil) are also not approved by the US Food and Drug Administration (FDA) for medical use whatsoever.
State laws have a little bit more play in them and diverge from the federal stance to different degrees. The use of marijuana to treat some medical conditions is legal in many states even though it remains federally banned. Each state has individual rules about how they deal with marijuana so it is important to research the specific rules for your state.
Dronabinol (pharmaceutical THC) and some synthetic cannabinoid drugs like Marinol are approved by the FDA. Marinol is used to relieve nausea and vomiting for chemotherapy patients in addition to being prescribed to AIDS patients for appetite stimulation.

Marijuana is more than THC.

Different compounds found in marijuana have affect the human body in different ways. For example, delta-9-tetrahydrocannabinol (THC) causes the mental high and can also relieve pain and nausea. At the same time it can reduce inflammation and act as an antioxidant. Cannabidiol (CBD) can help treat seizures, can reduce anxiety and paranoia, and can counteract the “high” caused by THC according to the American Cancer Society.
Different cultivars (strains or types) of marijuana can have varying amounts of the different cannabinoids. The specific ratio of cannabinoids produced by a plant is known as it’s strain profile and can be used to better judge what effects to expect from a specific strain.
The effects of marijuana also change depending on how it enters the body:

  • When inactivated or raw cannabis is eaten, the THC is absorbed poorly by the body. Once absorbed, it’s processed by the liver into a second psychoactive compound. The second substance acts on the brain to change mood and/or consciousness differently than THC.
  • When marijuana is smoked or vaporized, THC enters the bloodstream quickly, bypassing the liver at first. It is transported to the brain before the liver can convert a large amount of it into the second chemical. Because there is so much less of the second chemical, the high is stronger but fades quicker.

What can marijuana treat?

A number of studies using small groups of marijuana users found that cannabis can be helpful for treating nausea and vomiting from cancer chemotherapy. A few studies have found that smoked or vaped cannabis can be helpful in the treatment of neuropathic pain as well.
Smoked marijuana has also helped improve food intake in certain HIV patients during some studies. Clinical trials have also been shown marijuana extract users tended to need less pain medication than others. The pain relieving effects seem to be even better in the non-psychoactive cannabinoid CBD than with THC.

How does marijuana affect cancer?

According to the American Cancer Society, “…THC and other cannabinoids such as CBD slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer.” While there have been some early clinical trials of cannabinoids in treating cancer, future studies are inevitable.
Most studies show cannabinoids can be safe in treating cancer. They do not however seem to help control or cure the disease. Relying on marijuana alone as treatment while avoiding or delaying conventional medical care for any issue (including cancer) may have serious health consequences.

What are the possible harms of marijuana?

While many insist marijuana can pose no harm to users, it is not true. The most common effect of marijuana is a feeling of euphoria. Yet the complex chemistry of the brain and cannabinoids indicates that there is a lot going on under the hood. Cannabis can lower the user’s control over movement, cause disorientation, and sometimes cause unpleasant thoughts or feelings of anxiety and paranoia. While the majority of users do not experience these negative effects, they are more common in new users who don’t understand their dosing requirements.
Smoked marijuana delivers THC and other cannabinoids to the body along with harmful substances. Tar is one of the substances found in both tobacco and cannabis smoke. Heavy users (more than one gram a day) of smoked cannabis also commonly report chronic bronchitis.

Make sure to do research.

Because marijuana plants come in different strains with different levels of active compounds, it can make each experience different. Even with good data from a state certified lab, the effects of a specific strain on a specific user can be very hard to predict. It can take time and experimentation to find the best treatment plan or strain for a specific issue.
Even though cannabis is not chemically addictive (like caffeine or an opioid) people can still become psychologically dependant. Users will not receive the life threatening withdraws like they do from cocaine but they may still feel the conditioned desire to use.  Treatments and attitudes toward addiction vary widely across countries and the globe. If you struggle with addiction or are interested in treating any malady, it is best to seek a spectrum of qualified professional help before committing to any treatment plan. Make sure to get more than your own opinion before you make potentially life altering decisions. Thanks for reading.

canna

Terpenes: The Arousing Aroma of Cannabis

Have you ever wondered what makes cannabis smell the way it does?

There is a lot of chemistry when it comes to terpenes. There is still a lot to unlock about how our bodies process the chemicals that make things smell. We call these chemicals aromatics and terpenes are the specific types of aromatics produced by plants including cannabis.
Many recent advancements in the science of biology and biochemistry have opened windows into how we experience terpenes. Most people can tell the difference between the smell of lemons and mushrooms because the chemicals they produce interact with our bodies differently. They interact with our endocannabinoid system through CB-1 and CB-2 receptors the same way THC and CBD do.

How do terpenes work?

Terpenes have a synergistic effect with cannabinoids as their complex chemistry is able to shift and flex. Because of their flexibility, they can be used by the body to work for many different uses. Terpenes can affect dopamine and serotonin production and destruction while limonene can increase serotonin production. This is why different strains not only smell and taste different, but also have different affects on mood or sensation.
While over 200 terpenes occur in different concentrations in any given strain, there are a few primary terpenes that produce the greatest concentrations, and about 20 more secondary terpenes that occur in lesser concentrations. Each terpene has a specific purpose and more research is needed to reveal the true complexity of their chemistry.

What are the primary terpenes?

Of all the hundreds of terpenes, there are only a few that are produced in any great abundance. There are about 12 main terpenes in cannabis. Different strains produce terpenes in different amounts and are therefore specialized to treat different maladies. Here are the most common terpenes and what they do.
Myrcene: Is an effective anti inflammatory. It also works as a sedative and muscle relaxer.
Linalool: Can be used as an anti inflammatory and can also modulate motor movements.
Limonene: Can be used to help promote weight loss, prevent and treat cancer, and treat bronchitis.
Alpha Bisabolol: Can heal wounds, fights bacteria, and can also be used a deodorizer.
Delta 3 Carene: Is an effective anti inflammatory. It is also known to dry fluids like tears, running noses, and menstrual flows.
Borneol: Can be used as an analgesic, anti-septic, and bronchodilator.
Pinene: Has anti-inflammatory properties.
Eucalyptol: Is used in cough suppressants, mouthwash, and body powder.
Terpineol: Contains antioxidant properties.
Caryophyllene: May help treat anxiety and depression.
Camphene: Is known to possess anti-inflammatory and antibiotic characteristics.

Testing for terpenes can be done two ways.

Most consumers have a passing knowledge of what terpenes they want. They try a few strains and develop a preference for one over another. A quick sniff of a sample is all that is needed for a broad sense of what is present. Trying to peel apart the individual layers takes a more nuanced approach though.
Myrcene and linalool are some of cannabis’s most abundant terpenes. Myrcene smells musky, like cloves or an earthy, herbal scent. Some even say it has notes of citrus and tropical fruit. Linalool on the other hand smells like a  candy or  a sweet floral element. The more fragrant a strain, the more terpenes are present and active.
Because of how many different aromatic terpenes cannabis produces, it can be difficult to determine the exact mix of terpenes by smell alone. Most producers or distributors rely on chemical analysis. They get the exact level of terpenes through a report from a certified testing lab. The same labs that test for THC and CBD content are often equipped to also perform terpene analysis for a small fee.

Plants produce terpenes for a variety of reasons.

Plants can’t run away from predators or bad weather. Because they can’t flee, they have developed many ways to deal with the inevitable. One of the ways plants cope is by producing chemicals like cannabinoids and terpenes. Terpenes like pinene and limonene are able to ward off plant predators while linalool and myrcene can help the plant heal from injury.
Plants can also use terpenes to call for help. There is evidence that even corn uses terpenes like those found in cannabis to protect itself from predators. It doesn’t use the terpene to kill anything, it uses it to call for reinforcements. Corn roots damaged by pesky caterpillars emit caryophyllene. This terpene attract predatory wasps that then attack the caterpillars.

Different plants produce the same terpenes.

Cannabis produces terpenes in the same trichomes that it uses to produce cannabinoids like THC and CBD. The cannabis plant smells strongest during flowering because that is when the most trichomes are active. Natural variation and forced breeding techniques have allowed people to design plants based on cannabinoid content as well as terpene content.
Biology is complex but there are repeating patterns. Most plants require the same chemicals (Nitrogen, Phosphorus and Potassium) as they do to produce smells (terpenes). Cannabis produces the same terpenes as other plants, just in different amounts.

Terpenes enhance the effects of cannabinoids.

Take myrcene, it occurs in fragrant plants and herbs like mangoes, hops, bay laurel leaves, thyme, lemongrass, and basil. It is naturally synergistic with THC and allows cannabinoids to more easily bridge the blood-brain barrier. Myrcene is present in most cannabis although it is a dominant terpene in Pure Kush, Jack Herer and many other strains.
Over generations of breeding, cannabis cultivators have selectively bred plants to produce high levels of specific mixes of terpenes. Strains like Lemon Skunk and Sour Lemon have higher levels of limonene in them while Dog Walker and Skunk normally produce more myrcene.

Orin-Ray Terpenes

Do terpenes just make things smelly?

Terpenes determine many of the effects attributed to specific strains. While two samples may have the same THC content, if their terpenes profile (mix of terpenes present) are different, the samples will affect someone in different ways. Strains like Granddaddy Purps or OG Kush are generally sedating while Sour Diesel and Strawberry Cough tend to increase alertness.
Humans have inhaled terpenes, including linalool, since ancient times to help relieve stress, fight inflammation, and combat depression. Linalool specifically has been the subject of many studies. Some, like this one where scientists had lab rats inhale linalool while exposing them to stressful conditions, reported that linalool returned their immune system stress levels to near-normal.
We still need to do more research to find all of the ways that terpenes interact with our bodies. As legalization sweeps the country, hope for more research funding is growing. For now, people in states that have legalized cannabis in some way can begin doing anecdotal research themselves. Thanks for reading.

cann history

A History of Medical Cannabis Part 2: Modern Cannabis

In Part 1 we talked about ancient cannabis and how it has been used throughout the ages.

Today we are going to talk about modern cannabis and how it moved from prominence as a medicine to a recreational drug. Yet medical cannabis is not relegated to the ancient past. Modern medicine uses the term marijuana instead of the ancient name: cannabis but it means the same thing.
The original name can be traced back to the Greek physician Pedanius Dioscorides. He was a roman army doctor from around 40-90AD who traveled widely on campaigns throughout the Roman empire. He wrote the medical text that virtually all others were based on for over a thousand years and had a special entry for both male and female cannabis plants. It wasn’t until the 1930’s when the plant became known a marijuana in an effort to re-brand it. But I’m getting ahead of myself.

By 1621, medical marijuana had made its way into the English Mental Health Book.

Cannabis was entered into one of the most popular medicinal textbooks from the era to treat depression. Because of the work of an Irish doctor working for a shipping company during the colonization of the new world, medical cannabis moved to the Americas.
Cannabis treatments were a staple of a professional doctors curriculum up through the industrial revolution.  Before Alaska and Hawaii were states, America had laws on the books that supported medical marijuana in all 48 states. Cannabis was not seen as a recreational drug, it was medicine with little risk of side effects.

But in 1936 all that changed.

Pressure was being placed on the U.S. by the international community to sign the International Treaty on Controlled Substances. While not directly listing cannabis as a controlled substance, the treaty forced all countries that signed to adopt similar drug policies. Propagandists later used the treaty to get cannabis banned across the developed world.
A very popular anti-marijuana campaign burned through the nation. Funded by the government and directed by the talented propagandist Larry Anslinger, “Reefer Madness” was a sensational tale about marijuana. It featured the plant ruining people’s lives through sex, insanity, and horrific acts of violence. Although Reefer Madness was a work of pure fiction,  it was accepted by a whole generation as fact with the tenacity of religious convictions. The influential power of the Reefer Madness propaganda laid the groundwork for Larry Anslinger to get cannabis banned.
Larry Anslinger was a potent propagandist that was able to convince the developed world to outright ban cannabis use, cultivation and distribution. He used a mixed media of propaganda to accomplish this. Anslinger was a master of using media and used the newspapers, radio and television to spread a web of half-truths and outright lies.
After spreading a racially motivated panic with the Reefer Madness propaganda, Anslinger convince the U.S. to pass the Marijuana Tax Act of 1937. Anslinger provided his political masters a new way to target their political opponents voting base. The politically motivated police force acted quickly on the new laws to target the poor.

The Marijuana Tax Stamp Act brought America Modern Cannabis.

On the day the Marijuana Tax Stamp Act was enacted (Oct. 2, 1937) the FBI and Denver Colorado police raided the Lexington Hotel. They arrested a man named Samuel R. Caldwell for selling modern cannabis. He was a 58 year-old unemployed laborer. Three days later, on Oct. 5, 1937 Caldwell became the first person convicted under U.S. federal law of distributing cannabis.
In 1942, cannabis was removed from the U.S. Pharmacopeia. When that happened, cannabis lost the last vestiges of medical legitimacy. Because of the International Treaty on Controlled Substances, most of the other countries in the developed world were forced to enact similar rules.

Over the next decades, criminalization of cannabis continued.

As more and more regulations were heaped on medical practitioners, they became unable to prescribe cannabis. Legal penalties increased massively with the Boggs Act of 1951. It established minimum prison sentences for simple possession of cannabis. Thanks in great part to Anslinger’s work, cannabis was classified as a schedule 1 controlled substance in 1970.
Schedule 1 substances are substances no medical benefit and high risk of abuse. The controlled Substances Act of 1970 Classified Marijuana as a having “No Accepted Medical Use”. After the passing of the Substances Act, medical practitioners were barred from prescribing modern cannabis for any medication, effectively removing the oldest known medicine from a whole generation of healers across the globe.
In 1971, the Shafer Commission was created by the U.S. president to determine the merit of criminalizing cannabis. The Shafer Commission was bi-partisan and overseen by congress. President Nixon himself ordered it to determine “if the personal use of marijuana should be criminalized.” The commission came back with an answer and Nixon ignored it because he didn’t like that they believed there was no reason to scale up action against users.
In 1971 president Nixon chose to aggressively pursue action against cannabis consumers by declaring the War on Drugs. Motivated by personal prejudice political corruption, he saw marijuana as a way to get at his political opponents. He even admitted at the time that his reasons for attacking cannabis users and increasing penalties was motivated by personal directives.

Nixon acknowledged his action was not based on empirical evidence.

He increased criminalization despite the commission he put together telling him officially and unequivocally that cannabis use should not be criminalized. Over the next two years, the Nixon built a force specifically designed to scale up violence against modern cannabis users.
The Department of Drug Enforcement (DEA) was established in 1973 by merging the Bureau of Narcotics and Dangerous Drugs (BNND) and the Office of Drug Abuse Law Enforcement (ODALE) into a single agency. It comes as no surprise that the DEA continues to aggressively pursue cannabis consumers, producers and distributors to this day. They use every tool at their disposal regardless of legality or constitutionality to continue the criminalization of marijuana.
Things continued to go downhill for cannabis in the coming years. It wasn’t until 1976 that Robert Randall (who was afflicted by glaucoma) used the Common Law Doctrine of Necessity (US v. Randall) to defend himself against criminal charges of marijuana cultivation. In 1976, federal Judge James Washington made waves with his ruling. Judge Washington ruled that Randall’s use of modern cannabis constituted a ‘medical necessity’ and the case was thrown out.
Modern cannabis 2

The next milestone for modern cannabis crusaders came in the winter of 1991.

Modern cannabis took a step forward with the passing of medical marijuana reform in California. The first medical marijuana initiative was called Proposition P and was in San Francisco. It passed with an overwhelming 79% of the vote in November of 1991.
Proposition P called on the State of California and the California Medical Association to restore hemp medical to the list of available medicines in California, and to stop penalizing physicians for prescribing hemp for medical purposes. It only effected San Francisco but the cogs of bureaucracy had been activated. It would take another 5 years for legislation to go statewide.
Voters in California passed the first statewide medical marijuana initiative on November 5, 1996. Known as Proposition 215, it permitted patients and their primary caregivers to possess and cultivate marijuana for the treatment of AIDS, cancer, muscle spasms, migraines, and several other disorders. It also protected doctors from state sponsored punishment if they recommended marijuana to their patients.

The wheels of bureaucracy turn slowly.

In September of 1998, the House of Representatives debated a resolution called H.J.Res. 117. They passed H.J.Res 117 at the same time Oregon, Washington and Alaska provided their medical marijuana programs. In H.J.Res. 117, Congress declared support for the existing federal drug approval process.
They decide not to reschedule marijuana despite the overwhelming evidence coming forth that it should be decriminalized. While cannabis is classified as having no medical benefit, the United States Department of Health and Human Services) currently holds a patent on medical cannabis.
Patent No. 6630507 covers the use of cannabinoids for treating a wide range of diseases and was submitted to the patent office in 1999. The Department of Health and Human Services was awarded the patent in 2003. Yet the Department of Health is not the only regulatory agency that has chosen to abandon science, compassion and reason.
Modern Cannabis

In 2002, the FDA decided how to use modern cannabis in a study.

They decided that shipping 300 pre-rolled joints to patients in metal canisters was the best way to judge modern cannabis. The material was frequently two or more years old upon receipt by patients and a close inspection of the contents of NIDA-supplied cannabis cigarettes revealed them to be a crude mixture of leaf with abundant stem and seeds.
The study concluded that “cannabis smoking, even of a crude, low-grade product, provides effective symptomatic relief of pain, muscle spasms, and intraocular pressure elevations…” and that “clinical cannabis patients are able to reduce or eliminate other prescription medicines and their accompanying side effects.” The FDA report was ignored by those in power and cannabis remained a schedule 1 controlled substance despite the undeniable evidence.
The DEA has still not reclassified cannabis. It remains a holistic herb used throughout time as a medicine that current U.S. legislators are violently opposed to. While international progress has been made with the UK rescheduling cannabis to Class B and the Netherlands also making great strides in medicinal research, the U.S. still struggles to come into the light. Use of scientific reasoning is about to get even harder for the U.S. government as President Trump decides who will take the reigns of power. Yet his choice of Jim O’Neill to head the FDA (who openly supports cannabis legalization) gives modern cannabis hope for the future. Only time will tell. Thanks for reading.
Featured image: shutterstock

cbd wr

CBD: How Cannabidiol (CBD) is Natures Best Healing Compound

What is CBD?

Cannabidiol (CBD) is a naturally occurring compound found in cannabis plants.Scientific research over the last few decades has shown that Cannabidiol has dozens of medical benefits. Cannabidiol is one of over 60 compounds found in cannabis.  Both THC and CBD belong to a class of molecules called cannabinoids.
Of the known cannabinoid compounds, CBD and THC are usually present in the highest concentrations, and are therefore the most recognized and studied. The difference between CBD and THC comes down to how they interact with the cannabinoid 1 (CB1) receptors. Cannabidiol inhibits the interaction of CB-1 receptors throughout the body with a major focus on receptors in the central nervous system.
CBD Flower

How does CBD work in the body?

Cannabinoid receptors are cell membrane receptors  that contain transmembrane spanning properties. Cannabinoid receptors are activated by three groups of ligands (a molecule that binds to another molecule):  endocannabinoids that are produced inside the mammalian body, cannabinoids produced in plants and synthetic cannabinoids. Because CB-1 receptors bind with all three types of cannabinoids, one source can be supplemented for the other to provide medical benefit to patients.
The endocannabinoid system is a vast network of cell receptor proteins and serves many functions. CB-1 receptors are heavily concentrated in the central nervous system. Others types of cannabinoid receptors are found all over the body. They’re in every humans skin, digestive tract, and even in their reproductive organs. All of the endocannabinoids and plant cannabinoids bind to fatty compounds in the body. The binding properties of cannabinoids are why THC and CBD remain in a person’s system for so long.

How does CBD work in the brain?

Cannabidiol has low binding affinity for CB1 receptors. THC binds well with CB1 cannabinoid receptors but CBD does not. This is why one (THC) will cause a high and the other (CBD) will not. While this makes Cannabidiol a bad choice for recreational users, it is a significant advantage for use as a medicine. The high associated with cannabis is generally considered a side effect.
Since health professionals prefer treatments with minimal side effects. CBD is seen by most medical professionals as preferable to THC. CBD is non-psychoactive because it doesn’t act on the same pathways as THC. These pathways, called CB1 receptors, are highly concentrated in the brain and are responsible for the mind-altering effects of THC.
CBD Flower 1

What does CBD do?

The fact that Cannabidiol-rich cannabis is non-psychoactive or less psychoactive than THC-dominant strains makes it an appealing option for patients who want to avoid the stereotypical feelings associated with consuming cannabis.
Scientific and clinical research underscores Cannabidiol’s potential as a treatment for a wide range of conditions. People looking for relief from inflammation, pain, anxiety, psychosis, seizures, and other conditions without disconcerting feelings of lethargy find Cannabidiol to be an effective treatment.
Conditions including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders find the most relief from treatments. This is because CBD has demonstrable neuroprotective and neurogenic effects along with anti-cancer properties. These properties are currently being investigated at several academic research centers around the world.

How does CBD treat all these health issues?

The biggest distinction between CBD vs. THC comes down to a basic difference in how each one interacts with cannabinoid 1 (CB1) receptors. THC binds well with CB1 cannabinoid receptors while CBD does not. Think of it like an electrical plug connecting to an outlet.
A THC molecule is perfectly sized to connect with CB1 receptors. When that connection happens, THC stimulates those CB1 receptors like turning on a switch. THC works to activate those CB1 receptors.Cannabidiol works in a different way. It doesn’t act directly to activate or suppress CB1 receptors. Instead, it acts to suppress the CB1-activating qualities of a cannabinoid like THC.  So while THC turns on CB-1 receptors like sticking a key in an outlet, CBD blocks the outlet.

If CBD is so good, why isn’t it more mainstream?

Even though CBD shows great promise as a medicine, it remains illegal in most of the world. CBD is classified as a Schedule I drug (right beside THC) in the United States and a Schedule II drug in Canada and the UK.
The US government has been studying CBD for a while and fund most of the science going on stateside due to the difficulties associated in researching a schedule 1 substance. Even with the challenges, intrepid researchers have identified dozens of conditions that can be treated or cured using Cannabidiol.
A team of researchers at the California Pacific Medical Center, led by Dr. Sean McAllister, has stated that they hope to begin trials on CBD as a breast cancer therapy. Due to the challenges of navigating the FDA, they are fighting an uphill battle.

If CBD is great as medicine, why aren’t more drug companies using it?

All is not dark for CBD research. The U.S. Food and Drug Administration recently approved a request for a clinical trial of a CBD based drug. The drug in question is a pharmaceutical version of CBD used to treat children afflicted with rare forms of epilepsy. The drug is called Epidiolex and is made by GW Pharmaceuticals. GW Pharmaceuticals also makes another cannabis-based drug called Sativex.
Even with approval of trials for Cannabidiol based meds, the U.S. Drug Enforcement Agency (DEA) made it clear that marijuana-based extract is still considered a Schedule I drug under federal law. They made sure to say in a Dec. 2016 address that the ban includes CBD oils and other types of CBD-rich extracts.

What does the future of CBD look like?

In general, far more research is needed to figure out all of the effects cannabis has on our bodies. But, to say that our overall understanding of CBD is “lacking” would be an understatement. In the midst of medical and recreational legalization happening in the US state by state, the federal stance on cannabis remains staunchly opposed. While the UK classifies CBD as a schedule 2 substance, the US still tightly holds to its schedule 1 status of all things cannabis.
A pharmaceutical version of Cannabidiolwas recently developed by a drug company based in the UK. The UK based company, GW Pharmaceuticals, is now funding clinical trials on Cannabidiol as a treatment for schizophrenia and certain types of epilepsy through the significantly easier UK process.
Only time will tell if cannabis will become a mainstream medical tool in the future. With political pressure and overwhelming public support for legalization, there has been a lot of gains in recent years. As legislation moves cannabis out of the darkness and into the limelight, government agencies like the FDA will have to reevaluate how they have classified cannabis. Thanks for reading.
 

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A History of Medical Cannabis Part 1: Ancient Cannabis

Medical Cannabis is known by many names.

Whether you call it; ganja, weed, dope, grass, or the medical cannabis, it all means the same thing. Cannabis is one of the earliest plants known to be harvested by man. In fact, the oldest human artifact on record is an ancient sandal made from cannabis fibers known as hemp. The fibers of the cannabis plant were used in the oldest civilizations like Rome, Assyria, Egypt and China.
Some of the oldest known medicine was also made from cannabis. The earliest record of medical marijuana use was in 2900 BC by Chinese Emperor Fu. He and a majority of his citizens used the herb for medicinal purposes. From treating headaches and nausea to acting as an aphrodisiac, the ancient Chinese were pioneers in cannabis research.

Over the centuries, marijuana was used medicinally all over the world.

Many festivities and religious ceremonies involved cannabis as well. Cannabis was so important to ancient religious rites that it was an integral part of many rites including the process of anointing. Early Christians were well aware of how cannabis worked and used it in many of their most sacred rituals.
Christians inherited many of their religious practices directly from the Hebrews. The word Christ actually means ‘the anointed one’ and many scholars believe that Christ was anointed with chrism, a cannabis-based oil. The ancient recipe for this oil recorded in Exodus (30:22-23), included over 9 pounds of cannabis flower which the Hebrews called kaneh-bosem.
The Hebrews extracted the cannabis into about 11 pints of olive oil. This cannabis concoction was then mixed with a variety of other herbs and spices in very specific ways. The mixture was normally used in anointing and rituals that would allow the priests and prophets to commune with the divine.

Cannabis was used by more than just the ancient Chinese and Hebrews though.

India has a deep and long history with the plant.  Ancient chefs created a drink known as bhang out of cannabis paste, milk and spices. Shiva is said to have loved the drink so much that he took the title “Lord of Bhang”. Bhang has remained a medical remedy/ preferred beverage in India for centuries and is prepared there to this day. Zoroaster is also said to have listed cannabis as the most important of 10,000 medicinal plants.
The Indian Hemp Drugs Commission described the history and culture of cannabis in India: “To the Hindu the hemp plant is holy. A guardian lives in the bhang leaf… To see in a dream the leaves, plant, or water of bhang is lucky… No good thing can come to the man who treads underfoot the holy bhang leaf. A longing for bhang foretells happiness.”
Cannabis has been popular in India since the beginning of recorded history and is often drank. Nuts and spices like; almonds, pistachios, poppy seeds, pepper, ginger and sugar are mixed with cannabis and boiled in milk. Yogurt can also be used instead of milk. While popular in the east, bhang has never caught on with western pallets the same way.

Romans used Medical Cannabis as well.

The Greek physician Pedanius Dioscorides from around 40-90AD was a Roman army doctor who traveled widely on campaigns throughout the Roman empire. He studied many plants, gathering his knowledge and assembling it into a book he titled De Materia Medica (On Medical Matters).
Published around 70AD, De Materia Medica became the most important medical text for the next 1500 years. Virtually all medical texts were based off of this single work. Within its pages were contained the most important and useful plants known to mad. Included in the tome was cannabis, both kannabis emeros and kannabis agria, the male and female respectively. Dioscorides stated bluntly that the plant used in the making of rope also produced a juice that treated earache and suppress sexual longing.

Even the Egyptians were into medical cannabis.

In the ancient world, Egypt was a center of trade and information. Their position at the mouth of the Nile provided a base of strength for millennia. Part of that strength was advanced medical techniques that were passed down through the use of writing. Ancient Egyptian doctors and pharmacologists would use papyrus to record their work.
One of the oldest texts to survive to modernity is the 2nd century Fayyum Medical Papyrus. This ancient Egyptian text is believed to contain the earliest record of cannabis as an ingredient in cancer medicine. While they didn’t record enough for us to assess the successes of ancient Egyptian cancer treatments, cannabis continues to receive interest as a cancer therapy today.
Cannabis pollen was even found on the mummy of Ramesses II. He was a powerful Pharaoh who died in 1213 BC. It is unclear how the cannabis was used but prescriptions for cannabis in Ancient Egypt also included treatment for the eyes (glaucoma), inflammation, cooling the uterus, as well as administering enemas.

Cannabis is actually new to the Americas.

By the late 1700s, American medical journals began recommending hemp seeds and roots for the treatment of inflamed skin, incontinence and venereal disease. But it was Irish doctor William O’Shaughnessy who first popularized marijuana’s medical use in England and America.
O’Shaughnessy was a physician with the British East India Company during the years leading up to the American Revolution. He found marijuana eased the pain of rheumatism and was helpful against discomfort and nausea. Patients were prescribed cannabis most for cases of rabies, cholera and tetanus. Truly, Dr. O’shaughnessy was an integral part of the rise of medical cannabis in Europe and the Americas.

In the age of scientific innovation, cannabis was in medical texts.

In 1621, medical marijuana made its way into the English Mental Health Book, the most popular medicinal textbook from the time. Of all the things it could have suggested, it recommends marijuana to treat depression, the same as modern scientific research has shown.
Early Settlers had cannabis but mainly used it for fiber. The Jamestown settlers brought the marijuana plant specialized to produce fiber commonly known as hemp, to North America in 1611.
Throughout the colonial period, hemp fiber was an important export. By 1762, cannabis cultivation can become so common that Virginia awarded bounties for hemp culture and manufacture along with imposing penalties on those who did not produce it.

It wasn’t until the 1900’s that cannabis lost its medical, economic and spiritual prominence.

With the invention of television and the consolidation of media during the 1900s, cannabis moved from medical staple to outcast with surprising speed. Due to the efforts of Larry Anslinger and his associates, medical cannabis was stripped from medical texts and scientists were effectively banned from studying it.
Top image: Bigstock

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What Tetrahydrocannabinol or THC is used for

Dozens of years of research indicate many restorative uses for THC.

Tetrahydrocannabinol or THC, is often the most desired chemical found in cannabis. It is best known for bringing on the high that weed is known for. As one of the few compounds found in cannabis that is psychoactive, doctors and scientists have discovered many ways to utilize THC.
The extraction of pure Tetrahydrocannabinol was perfected by an Israeli physicist named Raphael Mechoulam. In 1964, Mechoulam separated and blended THC from Lebanese hashish, denoting the start of cannabis research that would prompt to the revelation of various different cannabinoids and how they interact with the body.
While the discoveries have been many and inspiring, they are not without their doubters. The federal government has classified cannabis as a schedule 1 drug meaning it has no medical benefit. This is in addition to the government obtaining patents for the neuro-protective capabilities of cannabis.
Be that as it may, while chemicals like cannabidiol (CBD) have begun to pick up support because of their absence of psychoactivity, many years of research have uncovered various health advantages one of a kind to THC. Here are a few of the most common uses.

Tetrahydrocannabinol relieves some types of pain.

A standout amongst the most common uses of therapeutic weed is for pain treatment. Upon closer examination, evidence has shown that Tetrahydrocannabinol interacts with the central nervous system to prevent the transmission of certain types of pain. Moreover, cannabis has been appeared to be particularly successful against neuropathic agony, or nerve-related pain.
The nerve signals that our brains sense as pain come from special cells with receptors on them. They become activated by temperature, touch, movement, or chemical changes in their environment. Pain signals arise and travel to the brain by one of three main pathways, each of which produces different pain sensations: somatic, visceral, and neuropathic.

There are three types of pain in general.

is the feeling most people recognize when they think about pain: a message sent by receptors located throughout the body whenever injury occurs. Somatic pain signals travel to the brain through nerves bundles and are typically experienced as a constant, dull ache. THC is able to reduce swelling and other contributing factors to somatic pain but in general is not very effective treatment.

 

occurs when skin or organs in the abdomen become stretched or otherwise disturbed from disease or injury. Pain signals issue from a special class of receptors present in the gut, producing feelings of pressure deep inside the body. Visceral pain can seem to be coming from different parts of the body than its actual source. THC is able to counteract feelings of nausea and many elements of chronic visceral pain.

 

occurs when the nerves are injured. It is often experienced as a burning sensation that can occur in response to even a gentle touch. Neuropathic pain usually doesn’t respond to narcotic painkillers making it stand out from the other types of pain. Antidepressant or anticonvulsant drugs, along with surgical procedures normally treat this type of pain but THC has also been found to be highly effective.

 
Cannabis is an excellent plant that has shown surprisingly positive results as a neuropathic treatment. The Tetrahydrocannabinol within that cannabis is able to work on a level that crosses many typical treatment boundaries. Pain treated by THC may be acute or chronic, blindingly intense or mind-numbingly dull. The pain can be momentary or have persisted for days to years.
However long it takes before a patient tries cannabis, it doesn’t take long for them to finally find relief. For acute pain, such as the discomfort that follows surgery, doctors typically prescribe opiates: narcotic drugs derived from, or chemically similar to, opium.

THC is better at dealing with some types of pain than opiates.

During the short-term treatment of intense pain, opiates offer significantly stronger relief for most patients. For chronic pain however, the tables turn in favor of Tetrahydrocannabinol. Treating chronic pain with opiates rarely brings relief.
Chemical dependence also becomes an issue with opiates as usage continues. Cannabinoids like THC have been proven to be non-addictive and highly effective for chronic pain. These differences combine to show that cannabinoids have significant promise in neuroscience and fundamental understandings of pain.
Peripheral nerves that detect pain sensations contain abundant receptors. Many of these receptors are tailor made for cannabinoids. According to research, cannabinoids appear to block peripheral nerve pain in experimental animals. Even more encouraging, some initial studies suggest that opiates and cannabinoids suppress pain differently.
If that is the case, marijuana-based medicines could combine with opiates to boost pain-relieving power while limiting the side effects. There are real hurdles to overcome if the initial Tetrahydrocannabinol research holds up. With the exponential expansion of scientific frontiers in recent decades and the recent deregulation of cannabis in over 26 states, we should have a significantly better understanding in the next decade.

Some people even use Tetrahydrocannabinol to treat PTSD.

Post traumatic stress disorder has only recently been classified in the Diagnostic and Statistical Manual (DSM) compared to other psychosomatic issues. PTSD is tied to traumatic memories and affects people from every walk of life. Soldiers, doctors, librarians and children can all have PTSD. Finding a safe treatment for so many different demographics is almost impossible.
Discovery of the endocannabinoid system by Dr. Mechoulam made safe treatment of PTSD, along with Parkinson’s and Cerebral Palsy a possibility. Since its discovery in the 1950’s, science has learned that Tetrahydrocannabinol is pharmacologically plastic. By manipulating the endocannabinoid system with THC and other cannabinoids, doctors are able to offer relief to patients that would otherwise have none.

We need more research to discover all that THC has to offer.

With the federal government classifying cannabis as a schedule 1 narcotic, it makes research in America almost impossible. There are some states like Oregon, Washington, California and many others that have taken steps to end Tetrahydrocannabinol prohibition but the fight is far from over.
Scientists can’t study cannabis if government continues to demonize it. As more states join the green revolution, it puts pressure on federal legislators to rethink their stance on legalization. If the community is able to enact declassification of cannabis it will remove the final argument against full legalization.
Once cannabis is removed from the scheduled substance list, we will finally put the whole scientific community to work, not just one Israeli scientist. No disrespect to Isreal, it’s just that cannabis is grown in other places to. We shouldn’t be stopping the Jamaican, American or Ukrainian scientific communities from contributing to THC research.
Thanks for reading.

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THC vs. CBD: What Do They Do?

Have you ever wondered what THC and CBD are?

For those who don’t know, tetrahydrocannabinol (THC) and cannabidiol (CBD) are potent chemical compounds produced in the trichomes on cannabis flowers. Trichomes are the small mushroom looking structures that sparkle like crystals in the light. Cannabis with a high concentration of THC or CBD is prized over just about anything else.
The states that allow cannabis sales require licensed retailers to prominently display the THC, CBD and possibly several other three letter words for everything with cannabis in it. People are always talking about how potent cannabis has become compared to times past and equating it with the THC and CBD content. This all points to THC and CBD being important, but why?
To start, cannabinoids are a group of compounds that our bodies and plants produce naturally. There are over 85 different cannabinoids identified so far with more just waiting to be catalogued. They are called cannabinoids because when Raphael Mechoulam  first identified them back in 1964, they were in the cannabis plants the Israeli doctor was studying.
Science has shown that our own bodies produce and process cannabinoids in immune and nerve cells. Humans are not unique in this ability to process cannabinoids either. The systems needed can be found in many mammals including dogs and cats.
Some animals simply can’t process THC and CBD. Insects like bees and ladybugs don’t have the right systems to be affected by the cannabinoids produced in cannabis. So even if insects or reptiles get covered in cannabinoids, it can’t get them high.
Science is discovering that the connection humans have to cannabis goes down to the molecular level. Continued research into the structure of THC and CBD has revealed that they are structural isomers. Essentially, they have the same basic parts but get arranged in a different way.

How do THC and CBD Work?

Cannabinoids like THC and CBD are able to bond with a special network or system of receptors in our cells. This system is present in most mammals, that is why cats and dogs will respond to cannabis in similar ways as you and I.
The specific receptors responsible for how weed makes us feel are called the CB1 and CB2 receptors. They were named after the different cannabinoids they are specialized to work with. I agree it’s not a very interesting name but being as simple as possible makes for easier science.
This system is called the endo-cannabinoid system. Endo for inside and cannabinoid for the type of chemical they work with. Cannabinoids like THC and CBD activate the receptors by mimicking the  neurotransmitters our bodies naturally produce called anandamides. Our bodies can’t tell the difference and accept the imposters without question. Yet each cannabinoid has a unique effect.

  • CB1 receptors respond to THC and are responsible for the psychoactive effects of cannabis. They are present in most of the brain and play a role in vital functions like; memory, mood, sleep, appetite and pain sensation. Cancer, insomnia, PSTD, MS, and many more disorders respond positively to CB1 stimulation.
  • CB2 receptors respond to CBD and are responsible for the anti-inflammatory effects of cannabis. They are found in immune cells and help reduce inflammation. Since inflammation is an immune response that is believed to be a factor in many diseases and conditions, controlling it can have life altering effects for people.

THC Ladybug

How are THC and CBD different?

THC is psychoactive, meaning it affects consciousness. Things like irritability, hunger and pain are all tied to brain function. THC reduces activity in the hippocampus, the part of the brain where memories are formed/stored). It also inhibits the amygdale, the part where the fight or flight instinct is stored/triggered.
If enough THC is added to the hippocampus, it can lead to a build-up of anxiety. Feelings of paranoia often accompany this negative reaction as the brain tries to deal with the elevated levels of cannabinoids. While no deaths have ever been recorded from weed alone, consuming cannabis does lead to reduced activity in certain parts of the brain.
While reducing brain activity is normally a bad thing, trauma and chemical imbalances can lead to hyperactivity in these brain areas. Conditions like PTSD and anxiety are examples where THC is one of the best treatments available. In fact, the VA recently made strides toward incorporating treatments into the framework of our military.
CBD is a totally different beast. It’s non-psychoactive, meaning it doesn’t affect consciousness directly. Yet it has been shown to have many beneficial properties. Things like swelling, decreased blood flow and seizures are all treatable by CBD.
Besides calming muscle spasms, CBD is able to counteract the psychoactive elements of THC. They have a balancing duality and because of their chemical similarities, it only takes a little acid to transition from THC to CBD and back again. Several companies have successfully synthesized cannabinoids already but it appears that the best effects come from natural plant sources.

How do we use THC and CBD?

Given that our bodies are hard-wired to benefit from cannabinoids, how do we get more? The oldest and most reliable way is to smoke some of the cannabinoid-rich trichomes that cover the cannabis flower. Vaporizing, eating and creating topical creams are also common ways to consume cannabinoids.
Modern extraction techniques exist that can produce almost 100% pure THC from raw plant matter. While this is the most potent/efficient way to consume THC, most commercial products range from 60-80%. Part of the reason lower percentage extracts are more common is the high cost of extremely pure THC or CBD comparatively.
Most people today consume cannabis in the form of food or concentrate to treat a malady or illness. Research has shown THC from smoking weed to be a neural-protector and helps slow/prevent Alzheimer’s. Cannabis can also provide relief to people suffering from neural conditions like Parkinson’s and Cerebral palsy. Patients often find more relief from their tremors, seizures and chronic pain than through other treatments.
Cannabinoids also play a part in the success of traditional cancer treatments like chemo therapy by stimulating appetite, relieving depression and reducing pain. While these benefits may seem minor, the increase in quality of life to these patients is measurable. Over time, the body will adapt to elevated cannabinoid levels so monitoring dosing is important.
Higher concentrations of THC and CBD are often needed for treatment of life threatening illness than can be found in raw cannabis. Over the centuries, this problem has been solved by refining the raw flower into concentrates. Products like BHO, PHO, RSO and CO2 extracts are excellent sources of concentrated THC to modern consumers.
Thanks for reading.