medicine Archives - Weed Reader

Medical, ScienceMarch 23, 2017 by Adam Rhodes

Cancer Treatments: Now With Marijuana

Marijuana is an old remedy.

Modern cancer patients aren’t the only people to understand the healing power of marijuana. Marijuana is the name given to the cannabis plant during 20th century prohibition. Cannabis grows wild in warm and tropical climates throughout the world and has been cultivated commercially for eons. Prohibition has given cannabis many other aliases as people developed code. Names like pot, grass, cannabis, weed, hemp, hash, hydro, ganja, and dozens of others all describe the same plant.
Records show marijuana has been used in herbal remedies dating back to the Chin Dynasty in China. Ancient doctors could see the effects of using cannabis as well as today and prescribed it for many maladies. The herb was so powerful that even the Romans put it in their medical texts.
Scientists have identified many biologically active components in marijuana that are the main reason it is so useful medically. These compounds are called cannabinoids. The two most studied of the hundred or so cannabinoids are delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD). Other cannabinoids are being studied but haven’t had the same amount of press or research put into them.

Is marijuana a legal treatment?

At this time, the US Drug Enforcement Administration (DEA) lists marijuana and cannabinoids as Schedule I controlled substances that cannot legally be prescribed, possessed, or sold under federal law. Whole or crude marijuana (including marijuana oil or hemp oil) are also not approved by the US Food and Drug Administration (FDA) for medical use whatsoever.
State laws have a little bit more play in them and diverge from the federal stance to different degrees. The use of marijuana to treat some medical conditions is legal in many states even though it remains federally banned. Each state has individual rules about how they deal with marijuana so it is important to research the specific rules for your state.
Dronabinol (pharmaceutical THC) and some synthetic cannabinoid drugs like Marinol are approved by the FDA. Marinol is used to relieve nausea and vomiting for chemotherapy patients in addition to being prescribed to AIDS patients for appetite stimulation.

Marijuana is more than THC.

Different compounds found in marijuana have affect the human body in different ways. For example, delta-9-tetrahydrocannabinol (THC) causes the mental high and can also relieve pain and nausea. At the same time it can reduce inflammation and act as an antioxidant. Cannabidiol (CBD) can help treat seizures, can reduce anxiety and paranoia, and can counteract the “high” caused by THC according to the American Cancer Society.
Different cultivars (strains or types) of marijuana can have varying amounts of the different cannabinoids. The specific ratio of cannabinoids produced by a plant is known as it’s strain profile and can be used to better judge what effects to expect from a specific strain.
The effects of marijuana also change depending on how it enters the body:

When inactivated or raw cannabis is eaten, the THC is absorbed poorly by the body. Once absorbed, it’s processed by the liver into a second psychoactive compound. The second substance acts on the brain to change mood and/or consciousness differently than THC.
When marijuana is smoked or vaporized, THC enters the bloodstream quickly, bypassing the liver at first. It is transported to the brain before the liver can convert a large amount of it into the second chemical. Because there is so much less of the second chemical, the high is stronger but fades quicker.

What can marijuana treat?

A number of studies using small groups of marijuana users found that cannabis can be helpful for treating nausea and vomiting from cancer chemotherapy. A few studies have found that smoked or vaped cannabis can be helpful in the treatment of neuropathic pain as well.
Smoked marijuana has also helped improve food intake in certain HIV patients during some studies. Clinical trials have also been shown marijuana extract users tended to need less pain medication than others. The pain relieving effects seem to be even better in the non-psychoactive cannabinoid CBD than with THC.

How does marijuana affect cancer?

According to the American Cancer Society, “…THC and other cannabinoids such as CBD slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer.” While there have been some early clinical trials of cannabinoids in treating cancer, future studies are inevitable.
Most studies show cannabinoids can be safe in treating cancer. They do not however seem to help control or cure the disease. Relying on marijuana alone as treatment while avoiding or delaying conventional medical care for any issue (including cancer) may have serious health consequences.

What are the possible harms of marijuana?

While many insist marijuana can pose no harm to users, it is not true. The most common effect of marijuana is a feeling of euphoria. Yet the complex chemistry of the brain and cannabinoids indicates that there is a lot going on under the hood. Cannabis can lower the user’s control over movement, cause disorientation, and sometimes cause unpleasant thoughts or feelings of anxiety and paranoia. While the majority of users do not experience these negative effects, they are more common in new users who don’t understand their dosing requirements.
Smoked marijuana delivers THC and other cannabinoids to the body along with harmful substances. Tar is one of the substances found in both tobacco and cannabis smoke. Heavy users (more than one gram a day) of smoked cannabis also commonly report chronic bronchitis.

Make sure to do research.

Because marijuana plants come in different strains with different levels of active compounds, it can make each experience different. Even with good data from a state certified lab, the effects of a specific strain on a specific user can be very hard to predict. It can take time and experimentation to find the best treatment plan or strain for a specific issue.
Even though cannabis is not chemically addictive (like caffeine or an opioid) people can still become psychologically dependant. Users will not receive the life threatening withdraws like they do from cocaine but they may still feel the conditioned desire to use. Treatments and attitudes toward addiction vary widely across countries and the globe. If you struggle with addiction or are interested in treating any malady, it is best to seek a spectrum of qualified professional help before committing to any treatment plan. Make sure to get more than your own opinion before you make potentially life altering decisions. Thanks for reading.

Analysis/Opinion, Culture, Marijuana Legalization, Marijuana News, Medical, ScienceFebruary 24, 2017 by Adam Rhodes

DEA: Marijuana is Not a Gateway Drug

Marijuana has been called a gateway drug for over 80 years.

The battle lines were drawn long before anyone currently driving the gateway debate had assumed power. Political figures have demonized cannabis and those who consume it for almost a century and worked to create a massive industrial prison complex designed to harvest people. Low income and minority people have borne the brunt of the assault.
Americans have been tricked into accepting the most ridiculous claims about cannabis and a whole generation of people have grown up behind bars because of it. Politicians have used slippery speech to sway public opinion and outright changed the law in order to suite their desires for decades. When Reagan and Clinton enacted laws that put more people in jail than the Romans had slaves.
Larry Anslinger didn’t care about how many would suffer without the healing properties of cannabis, he was motivated by an zealous hatred for the plant to create the movie Reefer Madness. President Nixon was motivated by a religious desire to punish people regardless of what his own investigators proved. Reagan had no mercy for people caught in the crossfire when he enacted draconian mandatory punishments for minor drug infractions.

We stand at the dawn of a new era of American drug policy.

Despite an abundance of empirical evidence about the medical benefit of cannabis from reputable medical professionals from the Shafer Commission to Sanjay Gupta, it remains a schedule 1 controlled substance. This classifies weed as having “no medical benefits” and creates massive hurdles for scientists and doctors looking to research cannabis. It also puts it in the same medical category as heroin.
With the rise of Trump and the appointment of Jeff Sessions to Attorney General, the entire industry is bracing for another impact. Part of the collective wince comes from the evasive actions of top officials on the matter through election season. Instead of giving clear messages about how they plan to pursue policy, government officials are as vague as possible about how they plan to pursue policy.
This evasive attitude has made many wary of the how the Trump Administration plans to deal with cannabis. Statements in the past by Jeff Sessions like “Good people don’t smoke marijuana.” and his past issues of discriminatory prosecution during the Civil Rights movement has helped to stir up old debates.

The debate surrounding legalizing marijuana has resurrected the Gateway Theory.

This theory presumes that experimenting with marijuana inevitably results in the use of harder drugs like cocaine, heroin and methamphetamine. Until recently, the DEA website contained dozens of lies and inaccuracies and it begrudgingly changed them only after being threatened with legal action.
Many people don’t know that it is illegal for federal agencies to spread incorrect information. Yet when it comes to cannabis, the Drug Enforcement Administration (DEA) has been doing it for years. In less than a month, a petition from Change.org calling on the DEA by a to stop lying about medical cannabis received 85,000+ signatures.
The petition was started by Americans for Safe Access (ASA), a nonprofit organization working to increase access to medical cannabis. “The DEA has actually admitted that the theories that cannabis use leads to harder drugs (gateway theory), long-term brain damage, psychosis, and other alleged harms, are not based in scientific fact, and yet they keep distributing this false information”, says ASA. “[W]e have found 25 instances of these false claims on their website.”

The petition for updated information was direct and their arguments were air-tight.

The group argued that the document previously known as “The Dangers and Consequences of Marijuana Abuse,” had a few inaccurate claims about cannabis. They showed how the page was in violation of the Information Quality Act which requires that administrative agencies provide accurate information to the public. The DEA also had to respond to requests for correction of information within 60 days.
A separate petition was filed by the Department of Justice demanding that the DEA immediately update misinformation about cannabis. While neither the DEA nor the DOJ responded to ASA’s request, the document which contained the majority of the inaccurate statements was removed from their website.
But the governement is made up of more people than ever before. There is a lot of room for competing ideologies and goals to play out. A key observation of the Shafer Commission is that many of the risks of drug use are the result of drug policy/enforcement rather than from the drugs themselves.

The “gateway drug” stigma refuses to die.

A prime example of how this stigma presents itself is New York governor Andrew Cuomo. He wants to keep cannabis illegal in New York State because it “leads to other drugs and there’s a lot of truth to proof that that’s true.” He holds this view despite the results of a major study on medical marijuana conducted by the venerable Institute of Medicine, which included an examination of marijuana’s potential to lead to abusing other drugs.
The study found that “There is no conclusive evidence that the drug effects of marijuana are causally linked to the subsequent abuse of other illicit drugs.” Even the DEA has gone on record to say “Little evidence supports the hypothesis that initiation of marijuana use leads to an abuse disorder with other illicit substances,” while refusing to reschedule cannabis in August of 2016.
The continuing stigma prevents meaningful reform of marijuana laws by perpetuating harmful misinformation. A Rasmussen poll found that a large percentage of Americans believe the gateway argument. Nearly half of voters (46%) believed marijuana use leads to harder drugs. Thirty-seven percent (37%) did not see marijuana as a “gateway” drug.

Patterns in progression of drug use are strikingly regular.

Because it is the most widely used illicit drug, marijuana is predictably the first illicit drug most people come across. Not surprisingly, most users of other illicit drugs used marijuana before the harder stuff. In fact, most adult users begin with alcohol and nicotine long before moving on to cannabis and other illicit drugs.
In 2006, the University of Pittsburgh released a thorough study which researchers spent 12 years putting together. They tracked a group of subjects from adolescence into adulthood and documented the initiation and progression of their drug use. The researchers reported that the gateway theory was not only wrong, but also detrimental to properly understanding and addressing drug abuse.
The myth of the Gateway effect needs to be put to rest once and for all. The more research that is conducted the clearer it becomes that cannabis use does not lead to abuse of other drugs. Some promising research has also shown that cannabis can actually help people kick the other stuff like heroine. As more and more states legalize medical and recreational marijuana, it is more important than ever to put the gateway myth to rest. Thanks for reading.

Analysis/Opinion, Guides, Medical, ScienceFebruary 13, 2017 by Adam Rhodes

Terpenes: The Arousing Aroma of Cannabis

Have you ever wondered what makes cannabis smell the way it does?

There is a lot of chemistry when it comes to terpenes. There is still a lot to unlock about how our bodies process the chemicals that make things smell. We call these chemicals aromatics and terpenes are the specific types of aromatics produced by plants including cannabis.
Many recent advancements in the science of biology and biochemistry have opened windows into how we experience terpenes. Most people can tell the difference between the smell of lemons and mushrooms because the chemicals they produce interact with our bodies differently. They interact with our endocannabinoid system through CB-1 and CB-2 receptors the same way THC and CBD do.

How do terpenes work?

Terpenes have a synergistic effect with cannabinoids as their complex chemistry is able to shift and flex. Because of their flexibility, they can be used by the body to work for many different uses. Terpenes can affect dopamine and serotonin production and destruction while limonene can increase serotonin production. This is why different strains not only smell and taste different, but also have different affects on mood or sensation.
While over 200 terpenes occur in different concentrations in any given strain, there are a few primary terpenes that produce the greatest concentrations, and about 20 more secondary terpenes that occur in lesser concentrations. Each terpene has a specific purpose and more research is needed to reveal the true complexity of their chemistry.

What are the primary terpenes?

Of all the hundreds of terpenes, there are only a few that are produced in any great abundance. There are about 12 main terpenes in cannabis. Different strains produce terpenes in different amounts and are therefore specialized to treat different maladies. Here are the most common terpenes and what they do.
Myrcene: Is an effective anti inflammatory. It also works as a sedative and muscle relaxer.
Linalool: Can be used as an anti inflammatory and can also modulate motor movements.
Limonene: Can be used to help promote weight loss, prevent and treat cancer, and treat bronchitis.
Alpha Bisabolol: Can heal wounds, fights bacteria, and can also be used a deodorizer.
Delta 3 Carene: Is an effective anti inflammatory. It is also known to dry fluids like tears, running noses, and menstrual flows.
Borneol: Can be used as an analgesic, anti-septic, and bronchodilator.
Pinene: Has anti-inflammatory properties.
Eucalyptol: Is used in cough suppressants, mouthwash, and body powder.
Terpineol: Contains antioxidant properties.
Caryophyllene: May help treat anxiety and depression.
Camphene: Is known to possess anti-inflammatory and antibiotic characteristics.

Testing for terpenes can be done two ways.

Most consumers have a passing knowledge of what terpenes they want. They try a few strains and develop a preference for one over another. A quick sniff of a sample is all that is needed for a broad sense of what is present. Trying to peel apart the individual layers takes a more nuanced approach though.
Myrcene and linalool are some of cannabis’s most abundant terpenes. Myrcene smells musky, like cloves or an earthy, herbal scent. Some even say it has notes of citrus and tropical fruit. Linalool on the other hand smells like a candy or a sweet floral element. The more fragrant a strain, the more terpenes are present and active.
Because of how many different aromatic terpenes cannabis produces, it can be difficult to determine the exact mix of terpenes by smell alone. Most producers or distributors rely on chemical analysis. They get the exact level of terpenes through a report from a certified testing lab. The same labs that test for THC and CBD content are often equipped to also perform terpene analysis for a small fee.

Plants produce terpenes for a variety of reasons.

Plants can’t run away from predators or bad weather. Because they can’t flee, they have developed many ways to deal with the inevitable. One of the ways plants cope is by producing chemicals like cannabinoids and terpenes. Terpenes like pinene and limonene are able to ward off plant predators while linalool and myrcene can help the plant heal from injury.
Plants can also use terpenes to call for help. There is evidence that even corn uses terpenes like those found in cannabis to protect itself from predators. It doesn’t use the terpene to kill anything, it uses it to call for reinforcements. Corn roots damaged by pesky caterpillars emit caryophyllene. This terpene attract predatory wasps that then attack the caterpillars.

Different plants produce the same terpenes.

Cannabis produces terpenes in the same trichomes that it uses to produce cannabinoids like THC and CBD. The cannabis plant smells strongest during flowering because that is when the most trichomes are active. Natural variation and forced breeding techniques have allowed people to design plants based on cannabinoid content as well as terpene content.
Biology is complex but there are repeating patterns. Most plants require the same chemicals (Nitrogen, Phosphorus and Potassium) as they do to produce smells (terpenes). Cannabis produces the same terpenes as other plants, just in different amounts.

Terpenes enhance the effects of cannabinoids.

Take myrcene, it occurs in fragrant plants and herbs like mangoes, hops, bay laurel leaves, thyme, lemongrass, and basil. It is naturally synergistic with THC and allows cannabinoids to more easily bridge the blood-brain barrier. Myrcene is present in most cannabis although it is a dominant terpene in Pure Kush, Jack Herer and many other strains.
Over generations of breeding, cannabis cultivators have selectively bred plants to produce high levels of specific mixes of terpenes. Strains like Lemon Skunk and Sour Lemon have higher levels of limonene in them while Dog Walker and Skunk normally produce more myrcene.

Do terpenes just make things smelly?

Terpenes determine many of the effects attributed to specific strains. While two samples may have the same THC content, if their terpenes profile (mix of terpenes present) are different, the samples will affect someone in different ways. Strains like Granddaddy Purps or OG Kush are generally sedating while Sour Diesel and Strawberry Cough tend to increase alertness.
Humans have inhaled terpenes, including linalool, since ancient times to help relieve stress, fight inflammation, and combat depression. Linalool specifically has been the subject of many studies. Some, like this one where scientists had lab rats inhale linalool while exposing them to stressful conditions, reported that linalool returned their immune system stress levels to near-normal.
We still need to do more research to find all of the ways that terpenes interact with our bodies. As legalization sweeps the country, hope for more research funding is growing. For now, people in states that have legalized cannabis in some way can begin doing anecdotal research themselves. Thanks for reading.

Culture, Marijuana Legalization, Marijuana News, Medical, ScienceFebruary 6, 2017 by Adam Rhodes

A History of Medical Cannabis Part 2: Modern Cannabis

In Part 1 we talked about ancient cannabis and how it has been used throughout the ages.

Today we are going to talk about modern cannabis and how it moved from prominence as a medicine to a recreational drug. Yet medical cannabis is not relegated to the ancient past. Modern medicine uses the term marijuana instead of the ancient name: cannabis but it means the same thing.
The original name can be traced back to the Greek physician Pedanius Dioscorides. He was a roman army doctor from around 40-90AD who traveled widely on campaigns throughout the Roman empire. He wrote the medical text that virtually all others were based on for over a thousand years and had a special entry for both male and female cannabis plants. It wasn’t until the 1930’s when the plant became known a marijuana in an effort to re-brand it. But I’m getting ahead of myself.

By 1621, medical marijuana had made its way into the English Mental Health Book.

Cannabis was entered into one of the most popular medicinal textbooks from the era to treat depression. Because of the work of an Irish doctor working for a shipping company during the colonization of the new world, medical cannabis moved to the Americas.
Cannabis treatments were a staple of a professional doctors curriculum up through the industrial revolution. Before Alaska and Hawaii were states, America had laws on the books that supported medical marijuana in all 48 states. Cannabis was not seen as a recreational drug, it was medicine with little risk of side effects.

But in 1936 all that changed.

Pressure was being placed on the U.S. by the international community to sign the International Treaty on Controlled Substances. While not directly listing cannabis as a controlled substance, the treaty forced all countries that signed to adopt similar drug policies. Propagandists later used the treaty to get cannabis banned across the developed world.
A very popular anti-marijuana campaign burned through the nation. Funded by the government and directed by the talented propagandist Larry Anslinger, “Reefer Madness” was a sensational tale about marijuana. It featured the plant ruining people’s lives through sex, insanity, and horrific acts of violence. Although Reefer Madness was a work of pure fiction, it was accepted by a whole generation as fact with the tenacity of religious convictions. The influential power of the Reefer Madness propaganda laid the groundwork for Larry Anslinger to get cannabis banned.
Larry Anslinger was a potent propagandist that was able to convince the developed world to outright ban cannabis use, cultivation and distribution. He used a mixed media of propaganda to accomplish this. Anslinger was a master of using media and used the newspapers, radio and television to spread a web of half-truths and outright lies.
After spreading a racially motivated panic with the Reefer Madness propaganda, Anslinger convince the U.S. to pass the Marijuana Tax Act of 1937. Anslinger provided his political masters a new way to target their political opponents voting base. The politically motivated police force acted quickly on the new laws to target the poor.

The Marijuana Tax Stamp Act brought America Modern Cannabis.

On the day the Marijuana Tax Stamp Act was enacted (Oct. 2, 1937) the FBI and Denver Colorado police raided the Lexington Hotel. They arrested a man named Samuel R. Caldwell for selling modern cannabis. He was a 58 year-old unemployed laborer. Three days later, on Oct. 5, 1937 Caldwell became the first person convicted under U.S. federal law of distributing cannabis.
In 1942, cannabis was removed from the U.S. Pharmacopeia. When that happened, cannabis lost the last vestiges of medical legitimacy. Because of the International Treaty on Controlled Substances, most of the other countries in the developed world were forced to enact similar rules.

Over the next decades, criminalization of cannabis continued.

As more and more regulations were heaped on medical practitioners, they became unable to prescribe cannabis. Legal penalties increased massively with the Boggs Act of 1951. It established minimum prison sentences for simple possession of cannabis. Thanks in great part to Anslinger’s work, cannabis was classified as a schedule 1 controlled substance in 1970.
Schedule 1 substances are substances no medical benefit and high risk of abuse. The controlled Substances Act of 1970 Classified Marijuana as a having “No Accepted Medical Use”. After the passing of the Substances Act, medical practitioners were barred from prescribing modern cannabis for any medication, effectively removing the oldest known medicine from a whole generation of healers across the globe.
In 1971, the Shafer Commission was created by the U.S. president to determine the merit of criminalizing cannabis. The Shafer Commission was bi-partisan and overseen by congress. President Nixon himself ordered it to determine “if the personal use of marijuana should be criminalized.” The commission came back with an answer and Nixon ignored it because he didn’t like that they believed there was no reason to scale up action against users.
In 1971 president Nixon chose to aggressively pursue action against cannabis consumers by declaring the War on Drugs. Motivated by personal prejudice political corruption, he saw marijuana as a way to get at his political opponents. He even admitted at the time that his reasons for attacking cannabis users and increasing penalties was motivated by personal directives.

Nixon acknowledged his action was not based on empirical evidence.

He increased criminalization despite the commission he put together telling him officially and unequivocally that cannabis use should not be criminalized. Over the next two years, the Nixon built a force specifically designed to scale up violence against modern cannabis users.
The Department of Drug Enforcement (DEA) was established in 1973 by merging the Bureau of Narcotics and Dangerous Drugs (BNND) and the Office of Drug Abuse Law Enforcement (ODALE) into a single agency. It comes as no surprise that the DEA continues to aggressively pursue cannabis consumers, producers and distributors to this day. They use every tool at their disposal regardless of legality or constitutionality to continue the criminalization of marijuana.
Things continued to go downhill for cannabis in the coming years. It wasn’t until 1976 that Robert Randall (who was afflicted by glaucoma) used the Common Law Doctrine of Necessity (US v. Randall) to defend himself against criminal charges of marijuana cultivation. In 1976, federal Judge James Washington made waves with his ruling. Judge Washington ruled that Randall’s use of modern cannabis constituted a ‘medical necessity’ and the case was thrown out.

The next milestone for modern cannabis crusaders came in the winter of 1991.

Modern cannabis took a step forward with the passing of medical marijuana reform in California. The first medical marijuana initiative was called Proposition P and was in San Francisco. It passed with an overwhelming 79% of the vote in November of 1991.
Proposition P called on the State of California and the California Medical Association to restore hemp medical to the list of available medicines in California, and to stop penalizing physicians for prescribing hemp for medical purposes. It only effected San Francisco but the cogs of bureaucracy had been activated. It would take another 5 years for legislation to go statewide.
Voters in California passed the first statewide medical marijuana initiative on November 5, 1996. Known as Proposition 215, it permitted patients and their primary caregivers to possess and cultivate marijuana for the treatment of AIDS, cancer, muscle spasms, migraines, and several other disorders. It also protected doctors from state sponsored punishment if they recommended marijuana to their patients.

The wheels of bureaucracy turn slowly.

In September of 1998, the House of Representatives debated a resolution called H.J.Res. 117. They passed H.J.Res 117 at the same time Oregon, Washington and Alaska provided their medical marijuana programs. In H.J.Res. 117, Congress declared support for the existing federal drug approval process.
They decide not to reschedule marijuana despite the overwhelming evidence coming forth that it should be decriminalized. While cannabis is classified as having no medical benefit, the United States Department of Health and Human Services) currently holds a patent on medical cannabis.
Patent No. 6630507 covers the use of cannabinoids for treating a wide range of diseases and was submitted to the patent office in 1999. The Department of Health and Human Services was awarded the patent in 2003. Yet the Department of Health is not the only regulatory agency that has chosen to abandon science, compassion and reason.

In 2002, the FDA decided how to use modern cannabis in a study.

They decided that shipping 300 pre-rolled joints to patients in metal canisters was the best way to judge modern cannabis. The material was frequently two or more years old upon receipt by patients and a close inspection of the contents of NIDA-supplied cannabis cigarettes revealed them to be a crude mixture of leaf with abundant stem and seeds.
The study concluded that “cannabis smoking, even of a crude, low-grade product, provides effective symptomatic relief of pain, muscle spasms, and intraocular pressure elevations…” and that “clinical cannabis patients are able to reduce or eliminate other prescription medicines and their accompanying side effects.” The FDA report was ignored by those in power and cannabis remained a schedule 1 controlled substance despite the undeniable evidence.
The DEA has still not reclassified cannabis. It remains a holistic herb used throughout time as a medicine that current U.S. legislators are violently opposed to. While international progress has been made with the UK rescheduling cannabis to Class B and the Netherlands also making great strides in medicinal research, the U.S. still struggles to come into the light. Use of scientific reasoning is about to get even harder for the U.S. government as President Trump decides who will take the reigns of power. Yet his choice of Jim O’Neill to head the FDA (who openly supports cannabis legalization) gives modern cannabis hope for the future. Only time will tell. Thanks for reading.
Featured image: shutterstock

Guides, Medical, ScienceFebruary 2, 2017 by Adam Rhodes

CBD: How Cannabidiol (CBD) is Natures Best Healing Compound

What is CBD?

Cannabidiol (CBD) is a naturally occurring compound found in cannabis plants.Scientific research over the last few decades has shown that Cannabidiol has dozens of medical benefits. Cannabidiol is one of over 60 compounds found in cannabis. Both THC and CBD belong to a class of molecules called cannabinoids.
Of the known cannabinoid compounds, CBD and THC are usually present in the highest concentrations, and are therefore the most recognized and studied. The difference between CBD and THC comes down to how they interact with the cannabinoid 1 (CB1) receptors. Cannabidiol inhibits the interaction of CB-1 receptors throughout the body with a major focus on receptors in the central nervous system.

How does CBD work in the body?

Cannabinoid receptors are cell membrane receptors that contain transmembrane spanning properties. Cannabinoid receptors are activated by three groups of ligands (a molecule that binds to another molecule): endocannabinoids that are produced inside the mammalian body, cannabinoids produced in plants and synthetic cannabinoids. Because CB-1 receptors bind with all three types of cannabinoids, one source can be supplemented for the other to provide medical benefit to patients.
The endocannabinoid system is a vast network of cell receptor proteins and serves many functions. CB-1 receptors are heavily concentrated in the central nervous system. Others types of cannabinoid receptors are found all over the body. They’re in every humans skin, digestive tract, and even in their reproductive organs. All of the endocannabinoids and plant cannabinoids bind to fatty compounds in the body. The binding properties of cannabinoids are why THC and CBD remain in a person’s system for so long.

How does CBD work in the brain?

Cannabidiol has low binding affinity for CB1 receptors. THC binds well with CB1 cannabinoid receptors but CBD does not. This is why one (THC) will cause a high and the other (CBD) will not. While this makes Cannabidiol a bad choice for recreational users, it is a significant advantage for use as a medicine. The high associated with cannabis is generally considered a side effect.
Since health professionals prefer treatments with minimal side effects. CBD is seen by most medical professionals as preferable to THC. CBD is non-psychoactive because it doesn’t act on the same pathways as THC. These pathways, called CB1 receptors, are highly concentrated in the brain and are responsible for the mind-altering effects of THC.

What does CBD do?

The fact that Cannabidiol-rich cannabis is non-psychoactive or less psychoactive than THC-dominant strains makes it an appealing option for patients who want to avoid the stereotypical feelings associated with consuming cannabis.
Scientific and clinical research underscores Cannabidiol’s potential as a treatment for a wide range of conditions. People looking for relief from inflammation, pain, anxiety, psychosis, seizures, and other conditions without disconcerting feelings of lethargy find Cannabidiol to be an effective treatment.
Conditions including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders find the most relief from treatments. This is because CBD has demonstrable neuroprotective and neurogenic effects along with anti-cancer properties. These properties are currently being investigated at several academic research centers around the world.

How does CBD treat all these health issues?

The biggest distinction between CBD vs. THC comes down to a basic difference in how each one interacts with cannabinoid 1 (CB1) receptors. THC binds well with CB1 cannabinoid receptors while CBD does not. Think of it like an electrical plug connecting to an outlet.
A THC molecule is perfectly sized to connect with CB1 receptors. When that connection happens, THC stimulates those CB1 receptors like turning on a switch. THC works to activate those CB1 receptors.Cannabidiol works in a different way. It doesn’t act directly to activate or suppress CB1 receptors. Instead, it acts to suppress the CB1-activating qualities of a cannabinoid like THC. So while THC turns on CB-1 receptors like sticking a key in an outlet, CBD blocks the outlet.

If CBD is so good, why isn’t it more mainstream?

Even though CBD shows great promise as a medicine, it remains illegal in most of the world. CBD is classified as a Schedule I drug (right beside THC) in the United States and a Schedule II drug in Canada and the UK.
The US government has been studying CBD for a while and fund most of the science going on stateside due to the difficulties associated in researching a schedule 1 substance. Even with the challenges, intrepid researchers have identified dozens of conditions that can be treated or cured using Cannabidiol.
A team of researchers at the California Pacific Medical Center, led by Dr. Sean McAllister, has stated that they hope to begin trials on CBD as a breast cancer therapy. Due to the challenges of navigating the FDA, they are fighting an uphill battle.

If CBD is great as medicine, why aren’t more drug companies using it?

All is not dark for CBD research. The U.S. Food and Drug Administration recently approved a request for a clinical trial of a CBD based drug. The drug in question is a pharmaceutical version of CBD used to treat children afflicted with rare forms of epilepsy. The drug is called Epidiolex and is made by GW Pharmaceuticals. GW Pharmaceuticals also makes another cannabis-based drug called Sativex.
Even with approval of trials for Cannabidiol based meds, the U.S. Drug Enforcement Agency (DEA) made it clear that marijuana-based extract is still considered a Schedule I drug under federal law. They made sure to say in a Dec. 2016 address that the ban includes CBD oils and other types of CBD-rich extracts.

What does the future of CBD look like?

In general, far more research is needed to figure out all of the effects cannabis has on our bodies. But, to say that our overall understanding of CBD is “lacking” would be an understatement. In the midst of medical and recreational legalization happening in the US state by state, the federal stance on cannabis remains staunchly opposed. While the UK classifies CBD as a schedule 2 substance, the US still tightly holds to its schedule 1 status of all things cannabis.
A pharmaceutical version of Cannabidiolwas recently developed by a drug company based in the UK. The UK based company, GW Pharmaceuticals, is now funding clinical trials on Cannabidiol as a treatment for schizophrenia and certain types of epilepsy through the significantly easier UK process.
Only time will tell if cannabis will become a mainstream medical tool in the future. With political pressure and overwhelming public support for legalization, there has been a lot of gains in recent years. As legislation moves cannabis out of the darkness and into the limelight, government agencies like the FDA will have to reevaluate how they have classified cannabis. Thanks for reading.

Analysis/Opinion, Culture, Medical, ScienceJanuary 29, 2017 by Adam Rhodes

A History of Medical Cannabis Part 1: Ancient Cannabis

Medical Cannabis is known by many names.

Whether you call it; ganja, weed, dope, grass, or the medical cannabis, it all means the same thing. Cannabis is one of the earliest plants known to be harvested by man. In fact, the oldest human artifact on record is an ancient sandal made from cannabis fibers known as hemp. The fibers of the cannabis plant were used in the oldest civilizations like Rome, Assyria, Egypt and China.
Some of the oldest known medicine was also made from cannabis. The earliest record of medical marijuana use was in 2900 BC by Chinese Emperor Fu. He and a majority of his citizens used the herb for medicinal purposes. From treating headaches and nausea to acting as an aphrodisiac, the ancient Chinese were pioneers in cannabis research.

Over the centuries, marijuana was used medicinally all over the world.

Many festivities and religious ceremonies involved cannabis as well. Cannabis was so important to ancient religious rites that it was an integral part of many rites including the process of anointing. Early Christians were well aware of how cannabis worked and used it in many of their most sacred rituals.
Christians inherited many of their religious practices directly from the Hebrews. The word Christ actually means ‘the anointed one’ and many scholars believe that Christ was anointed with chrism, a cannabis-based oil. The ancient recipe for this oil recorded in Exodus (30:22-23), included over 9 pounds of cannabis flower which the Hebrews called kaneh-bosem.
The Hebrews extracted the cannabis into about 11 pints of olive oil. This cannabis concoction was then mixed with a variety of other herbs and spices in very specific ways. The mixture was normally used in anointing and rituals that would allow the priests and prophets to commune with the divine.

Cannabis was used by more than just the ancient Chinese and Hebrews though.

India has a deep and long history with the plant. Ancient chefs created a drink known as bhang out of cannabis paste, milk and spices. Shiva is said to have loved the drink so much that he took the title “Lord of Bhang”. Bhang has remained a medical remedy/ preferred beverage in India for centuries and is prepared there to this day. Zoroaster is also said to have listed cannabis as the most important of 10,000 medicinal plants.
The Indian Hemp Drugs Commission described the history and culture of cannabis in India: “To the Hindu the hemp plant is holy. A guardian lives in the bhang leaf… To see in a dream the leaves, plant, or water of bhang is lucky… No good thing can come to the man who treads underfoot the holy bhang leaf. A longing for bhang foretells happiness.”
Cannabis has been popular in India since the beginning of recorded history and is often drank. Nuts and spices like; almonds, pistachios, poppy seeds, pepper, ginger and sugar are mixed with cannabis and boiled in milk. Yogurt can also be used instead of milk. While popular in the east, bhang has never caught on with western pallets the same way.

Romans used Medical Cannabis as well.

The Greek physician Pedanius Dioscorides from around 40-90AD was a Roman army doctor who traveled widely on campaigns throughout the Roman empire. He studied many plants, gathering his knowledge and assembling it into a book he titled De Materia Medica (On Medical Matters).
Published around 70AD, De Materia Medica became the most important medical text for the next 1500 years. Virtually all medical texts were based off of this single work. Within its pages were contained the most important and useful plants known to mad. Included in the tome was cannabis, both kannabis emeros and kannabis agria, the male and female respectively. Dioscorides stated bluntly that the plant used in the making of rope also produced a juice that treated earache and suppress sexual longing.

Even the Egyptians were into medical cannabis.

In the ancient world, Egypt was a center of trade and information. Their position at the mouth of the Nile provided a base of strength for millennia. Part of that strength was advanced medical techniques that were passed down through the use of writing. Ancient Egyptian doctors and pharmacologists would use papyrus to record their work.
One of the oldest texts to survive to modernity is the 2nd century Fayyum Medical Papyrus. This ancient Egyptian text is believed to contain the earliest record of cannabis as an ingredient in cancer medicine. While they didn’t record enough for us to assess the successes of ancient Egyptian cancer treatments, cannabis continues to receive interest as a cancer therapy today.
Cannabis pollen was even found on the mummy of Ramesses II. He was a powerful Pharaoh who died in 1213 BC. It is unclear how the cannabis was used but prescriptions for cannabis in Ancient Egypt also included treatment for the eyes (glaucoma), inflammation, cooling the uterus, as well as administering enemas.

Cannabis is actually new to the Americas.

By the late 1700s, American medical journals began recommending hemp seeds and roots for the treatment of inflamed skin, incontinence and venereal disease. But it was Irish doctor William O’Shaughnessy who first popularized marijuana’s medical use in England and America.
O’Shaughnessy was a physician with the British East India Company during the years leading up to the American Revolution. He found marijuana eased the pain of rheumatism and was helpful against discomfort and nausea. Patients were prescribed cannabis most for cases of rabies, cholera and tetanus. Truly, Dr. O’shaughnessy was an integral part of the rise of medical cannabis in Europe and the Americas.

In the age of scientific innovation, cannabis was in medical texts.

In 1621, medical marijuana made its way into the English Mental Health Book, the most popular medicinal textbook from the time. Of all the things it could have suggested, it recommends marijuana to treat depression, the same as modern scientific research has shown.
Early Settlers had cannabis but mainly used it for fiber. The Jamestown settlers brought the marijuana plant specialized to produce fiber commonly known as hemp, to North America in 1611.
Throughout the colonial period, hemp fiber was an important export. By 1762, cannabis cultivation can become so common that Virginia awarded bounties for hemp culture and manufacture along with imposing penalties on those who did not produce it.

It wasn’t until the 1900’s that cannabis lost its medical, economic and spiritual prominence.

With the invention of television and the consolidation of media during the 1900s, cannabis moved from medical staple to outcast with surprising speed. Due to the efforts of Larry Anslinger and his associates, medical cannabis was stripped from medical texts and scientists were effectively banned from studying it.
Top image: Bigstock

Guides, ScienceJanuary 27, 2017 by Adam Rhodes

NPK: The Essential Nutrients of Cannabis

How do I use NPK to grow the Best Cannabis?

If you are planning on growing cannabis, there is a lot of information to absorb. One of the most basic and important elements of growing great cannabis is making sure it has the right nutrients. Like any plant, cannabis has a special diet made up of three main elements. Instead of eating fats, protein and calories like humans, plants need nitrogen, phosphorus and potassium or NPK for short.
The three main nutrients are known as macro-nutrients and basically all plants need them to survive. From giant redwood trees to Venus Fly Traps, Nitrogen, phosphorus and potassium are the building blocks of a healthy plant. Yet not all plants require the same amount of each element so care is needed to provide the right mix of nutrients.

So how do I get the right mix of nutrients?

The easiest way to adjust the nutrient balance of soil is to add fertilizer. Modern cultivators have a wide range of products available to choose from. Most garden supply stores have a dizzying array of fertilizers in a myriad of forms. Liquid, solid, powder, organic, the list of methods for delivering nutrients to plants goes on. Each method or delivery system is keyed to different growing techniques but there is some basic info on every one of the bottles on the shelf.
All fertilizer has three numbers on it referred to as the NPK levels. The three numbers on fertilizer represents the value of the three macro-nutrients used by plants. These macro-nutrients are nitrogen (N), phosphorus (P) and potassium (K) or NPK for short.
Why do they call it NPK?
People have been growing plants for a LONG time. Some of the most important cultivators we have records of are the Greeks. Not because they were inherently special, but they helped propel language into a new era through conquest and trade so people often refer to them as founders of “Western Societies”. Greek also provided the root for the development of Latin. The Greek impact on cannabis cultivation permeates deeper than many understand.
Take the names of the nutrients; Nitrogen, Phosphorus and Potassium. Nitrogen is a French word coined in 1790 by Antoine Chaptal from Greek nitron “sodium carbonate” and French gène “producing,” which is itself a derivative from Greek -gen “giving birth to”.
Phosphorus comes from Greek φῶς and -φόρος (phos and phoros), which means “light bearer”. They called it that because white phosphorus emits a faint glow upon exposure to oxygen. Phosphorus was also the ancient name for Venus, or Hesperus, the (Morning Star) which has a faint glow. Then we get to Potassium which is often referred to as potash.
The English “potash” means “pot ash” as potassium is a compound prepared from an alkali extracted in a pot from the ash of burnt wood or tree leaves. Potash is a literal translation of the German potaschen, which means “pot ashes”. The symbol K is from the Latin name kalium, which means “calcined” or powdered ashes.

So how do I read the NPK values?

All modern fertilizer has the NPK values on the packaging. These values scale with potency. The higher the number, the more concentrated the nutrient is in the fertilizer. For example, fertilizer listed as 20-5-5 has four times more nitrogen in it than phosphorus and potassium. A 20-20-20 fertilizer has double the concentration of all three nutrients than one with 10-10-10.
Plants need nitrogen, phosphorus and potassium to grow. Without enough of any one of these nutrients, a plant will have issues and may even die. But they need each for different reasons. Nitrogen (N) is largely responsible for the growth of leaves and foliage on the plant. Phosphorus (P) is largely responsible for root growth and flower or fruit development. Potassium (K) helps the overall functions of the plant like stem development and water absorption perform correctly.

How do I know how much to use?

For cultivators working with prepared soil like Dakine 420 or Fox Farms, the level of nutrients in the soil is labeled. For cultivators working with native soil, getting a soil test is a great way to measure its health and fertility. These tests are generally inexpensive, but vital when it comes to growing and maintaining healthy plants in the garden.
Soil tests are used to determine the current fertility and health of your soil. Once a cultivator has this information, they can find the right formulation to bolster what is already there. Soil tests also show the pH in addition to macro-nutrient levels.
By measuring both the pH level and pinpointing nutrient deficiencies, a soil test can provide the information necessary for maintaining optimal fertility. Most plants, including grasses, flowers, and vegetables, perform best in slightly acidic soil (6.0 to 6.5). Others, like azaleas, gardenias and blueberries, require a somewhat higher acidity in order to thrive.

Why do most nutrients have a Veg and Bloom portion?

Not all plants require the same nutrients throughout their lives either. Marijuana requires a higher nitrogen ratio during the vegetative and early flowering stages as it is the main component for plant growth. During flowering the plant prefers a lower nitrogen and higher phosphorous NPK fertilizer ratio because phosphorus is important for flower and resin development. Adjusting the micro-nutrient levels can also change the absorption rates of macro-nutrients.
The NPK fertilizer ratio does not show the micro-nutrients. These are trace elements provided by most soils. They need to be added when using a hydroponic grow system. Having ‘hard water’ or water with calcium above 200 PPM makes adding more calcium counterproductive and can lead to nutrient lock-out. This is why several companies offer micro-nutrients for hard water.

So are all fertilizers with the same NPK interchangeable?

Even given the exact same NPK ratio, not all formulations are the same. The NPK elements of any fertilizer are bound up in molecular compounds with differing degrees of bio-availability. Companies may offer their nutrients as inorganic salts, oxides, or even as colloidal minerals. Depending on the individual system (soil, hydroponic, aeroponic) one method may be preferable over another.
Be sure not to mix nutrient lines from different manufacturers without knowing how their micro-nutrients interact. This is a difficult process for most without a chemistry degree so it is advised to see if other cultivators have experimented with identical mixtures. If their results are and mimic their process. Remember that order of operations is important and to follow their process exactly.

What should the NPK levels be?

Even more important than the actual numbers on the package is the ratio of each of the primary nutrients to each other. One cultivator can grow using nutrients with a rating of 15-30-15 and another can get identical results using 5-10-5 because the proportion of each nutrient is the same. During vegetative-growth, phosphorus levels should remain at about 1/2 of nitrogen levels. Potassium should be close to 1/2-2/3 that of nitrogen.
During flowering, phosphorus takes the lead. Keeping nitrogen at 1/2 and potassium at 1/2-2/3 the strength of phosphorus is a common benchmark. It is important to note that potassium is consistently maintained throughout both stages at 1/2-2/3 the level of the main nutrient. Staying close to this ratio will prevent a nutrient lock-out.
A nutrient lock-out is when nutrients combine to form compounds that your plant can’t use. Many liquid and powder nutrients need to be added in a specific order to prevent them mixing with other compounds and forming unusable compounds. Make sure to read the instructions on any nutrients used to prevent wasting product or damaging plants.

Thanks for reading.

Marijuana RecipesMarch 28, 2016 by GGG

Stoner Smoothies

Here are a few of my favorite smoothie recipes, altered to make your cannabis experience fresh, frozen, or drinkable. These will only really work if you use coconut oil-based cannabutter, since cream or dairy butter would be pretty nasty. It will incorporate best softened but not melted, and added in as scoops.

Extras: plant protein powder, mushroom powder blends, tea pollen, chia seeds, flax seeds

Each recipe should make either 1 large smoothie, or fill two 16 oz glasses.

THE RAW CBD (Choco-Banana-Dank)

2 or more tbs raw cacao powder

2 bananas

half an avocado

1 tbs almond butter

maple syrup or 2 pitted dates to sweeten

1/4 tsp cinnamon

1 tbs CBD oil

2 tbs canna-oil

soy, almond, or other nut milk

Blend all ingredients in blender until smooth. This smoothie is thick, very filling, and very chocolatey depending on how much cacao powder you add. For an easier drink, add more milk. You could also swap cinnamon for nutmeg, or protein powder, some lucuma powder, or another favorite add-in.

CBD (cannabidiol), for those unfamiliar, is one of the non psychoactive cannabinoids found in cannabis. From the Bluebird Botanicals website, where you can learn all about and purchase various CBD oils:

“Cannabidiol (CBD) is a naturally occurring constituent of agricultural hemp. It is the most abundant non-psychoactive cannabinoid in hemp/cannabis, and is commonly used as a food supplement to support general wellness.† Our CBD products are made from the highest quality, EU-certified hemp cultivars, which are grown in pristine soil in select European locations. Our CBD oils are constantly analyzed for their potency and purity from potential contaminants.”

Because it’s hemp-derived, the sale of CBD in the US is 100% legal, and Bluebird Botanicals ships anywhere in the US. In an upcoming review, I’ll speak more in-depth about BBB and a few of their products, as well as my experience in taking CBD oil.

But for now, a few benefits to consuming CBD:

-It contains essential amino acids, B, D, and E vitamins, and loads of trace minerals

-Improves flexibility, hair, skin & nails with essential fatty acids, Omega-3 and Omega-6 (note: the ratio of Omega-6 and Omega-3 in Americans is 10:1 or even 30:1 –way too high. Both work to produce anti-inflammatory proteins, but a 1:1 balance is needed to synthesize properly and effectively. Up your O3 intake with flaxseed [milled/ground/oil], chia seeds, walnuts, marine algae-based sources, or hemp oil.)

-Contains terpenes and flavonoids, which very basically affect smell and taste receptors.

Terpenes work both with taste and aroma in the plant or organic matter–in cannabis, they create the diverse perfume/scent profiles of each strain. Flavonoids give plants their pigmentation and in some cases, inhibit plant disease and infection, reduce inflammation and cholesterol, and have anti-cancer properties. Red, blue, purple, and yellow foods all contain anti-oxidants and most all foods contain flavonoids, and increasing consumption of color-rich foods like berries or dark chocolate could yield great benefit.

STRAWBERRY BANANA BLITZ

1 cup strawberries

2 bananas

1/2 cup dark or tart cherries

1/2 raspberries

1 or 2 cups orange or apple juice

2 tbs canna-oil

A puckered take on a sweet favorite. Blend together, use all fresh fruit for high fiber and store-bought consistency, or use frozen fruit for a smoothie more thick and slushy-like.

RAINBOW DREAM

cherries

raspberries

mango

orange juice

pineapple

banana

kale

honeydew melon

blueberries

blackberries

2 tbs canna-oil

Use apple or orange juice, since milk might cause some interesting flavor interaction. The basic idea is to include 1-2 fruits/veg of each color. In fact, the more colors in food in a day you can consume, the better! Like I said in the CBD smoothie recipe, richer colors means richer benefits. And, if you can, source organically & cruelty free.

A combination of fresh/frozen is best. You can make frozen fruit out of fresh fruit–just wash, slice, and lay out on wax paper & a baking sheet or silicone mat in the freezer until solid. Store chunks of fruit in tupperware or plastic bags. To make adding kale to smoothies way easier, do something similar–wash and cut up some fresh kale, let freeze in small piles or pack into an empty ice cube tray, then store once frozen.

COCONUT KALE AÇAI

kale

frozen açai berries or puree

full-fat coconut milk

coconut water

frozen mixed berries

canna-oil

For this smoothie, I’d recommend using some frozen kale, unless you’ve got a high-powered blender that can cut up leafy greens well. Otherwise blend 1/2 can coconut milk, 2 chunks of kale, a cup of açai berries or a puree packet, a handful of frozen mixed berries, canna-oil and coconut water as needed for desired consistency.

Sambazon ™ do 4 packs of frozen açai berry puree, sweetened or unsweetened. Fresh berries are harder to find unless you’ve got a bangin’ farmer’s market or specialty shops, so hit up the frozen section on your next food trip and see what they’ve got.

image credit: thestonerscookbook.com

Strain ReviewsDecember 3, 2015September 12, 2020 by WeedReader

Review: Mary's Medicinals Transdermal Patch

There’s a brand new product that has taken off the last couple years in the cannabis market: Mary’s Medicinals transdermal patch.
Available throughout Colorado dispensaries and now being introduced into the state of Oregon, these award-winning patches administer specific doses through the skin and straight into the bloodstream—which is the most efficient way to medicate.
They’re offered in doses of 10/20 mg and retail for around $10-15 each. So far they offer CBD, CBN, THC (indica/sativa), THCa, as well as blends of CBD:THC (whatever suits your liking). Each one has a recommendation for a specific application and/or symptoms.
We’ll focus on the THC (sativa) 10mg patch, suggested for the following; for relief from pain & anxiety, reduction of muscle spasms & nausea, promotion of sleep, & appetite stimulation.

Here are my findings:
The size of the patch is 2 in x 2 in, so fairly petite in size — a definite plus for the discreet user. I applied the patch to my wrist, which felt surprisingly comfortable and light on my skin. The adhesive didn’t feel heavy or sticky and my skin was still able to breathe.
There is a warning in the instructions stating that “burning or itching” may occur upon application, but I felt no such effects. It seems Mary’s went above and beyond with using high quality materials to manufacture their patches — Very nice!

30 min later — I felt a very subtle ‘sativa’ high, but nothing extravagant. I must admit, I was skeptical of the dosages and delivery system because I couldn’t imagine feeling a “high” from something that resembled a Band-Aid®. After slowly transitioning into the first “peak”, the patch seemed to have plateaued to a moderate type high. Perfect for the casual user, with little to no paranoia.
60 min later — At this moment, I felt another ‘wave’ of dosing enter into my body, another “peak”, if you will. This was a HUGE surprise for me. These “peaks” would last about 10 minutes, then the plateauing would follow. And for the next 6 hours the waves were like clockwork, releasing doses every 30 min.
6 hours later — Removing the patch from my skin was surprisingly easy and comfortable. Once the patch was removed, there was a bit of redness that lasted a few minutes, but I experienced no itching or irritation. The residuals from the adhesive was easily removed with little to moderate effort using soap and water.

Afterthoughts:
Overall, an excellent pharmaceutical grade, cannabis product! Strongly recommended for the traveling consumer and/or those suffering from chronic illness or long-term debilitating symptoms; especially pain, inflammation, insomnia, and cachexia.
Pros: The ease of use, discreet application, long-lasting effects and a relatively stable delivery system make for an incredibly efficacious product.
Cons: You don’t get the instantaneous “slap in the face” high you do from smoking or vaping. It just depends on what your preferences are.

A HUGE “Thank You!” to Mary’s Medicinals for their ingenuity in creating and distributing such a wonderful and viable product. These are exactly the kind of cannabis novelties we crave!
image credit: wikipedia.

ScienceSeptember 4, 2015 by Ben Neal

Cannabis: An All-Natural Sleep Aid?

It’s widely known that smoking weed can help reduce anxiety and stress, and generally help you relax and mellow out. So it makes sense that many people smoke before going to bed as a kind of “self-prescribed” sleep aid, and claim that it helps them to fall asleep faster and stay asleep longer.
However, those same people often have a difficult time sleeping without it. It takes them longer to fall asleep, and when they do they report having unusually intense and vivid dreams — even nightmares which are hyper-realistic and highly disturbing. Naturally, this can make it hard to stop smoking for whatever reason.
Then you’ve got other people who claim that marijuana makes them hyper, and causes their mind to race a mile-a-minute. Obviously, these folks wouldn’t dream of smoking pot at bedtime.
That’s the problem with a substance as chemically complex as cannabis. There are more than 80 naturally occurring cannabinoids in the plant, all of which could potentially have psychoactive effects. And each one of those compounds will affect each person differently, depending on their biochemistry.
The problem is made that much worse by the decades long ban on marijuana research, which has prevented us from properly studying cannabis and it’s medicinal properties, and gathering accurate data on how it affects different groups of people. We are forced to rely too heavily on anecdotal evidence, the “word on the street.”
The questions remain. Can marijuana really help you sleep? How does it affect your dreams and your sleep cycle? Can it be used as a safe and effective, all-natural sleep aid?
Let’s take a look…

Stoned Sleep Studies

Most of what we know about how cannabis affects the sleep cycle dates back to a 1973 study done on a group of insomniacs. The patients were given different doses of THC, from 10 – 30 mg, which were found to “significantly decrease the time it takes to fall asleep.” They also demonstrated some improvement in their ability to sleep through the night without waking up periodically.
The study also noted a “hangover effect,” which I for one am personally familiar with. (Sure, I may sleep soundly if I get high late at night; but in the morning I feel like I’ve been run over by a truck. I’m tired and sore, and can barely drag myself out of bed.)
The greater the dosage, the worse the hangover, the study found. So like most things in life, moderation is key. Smoking too much before bedtime can make you feel terrible the next morning, and even make it more difficult to fall asleep (or eliminate the urge and desire to fall asleep).
There have also been some more recent studies on the effects of synthetic THC on those suffering from sleep apnea. This research is in the early stages, but preliminary results are promising.

Stages of the Sleep Cycle

In addition to helping users to fall asleep faster, cannabis is also shown to alter their sleep cycle in interesting ways. For one thing, it seems to lengthen the amount of time that people spend in deep, “slow wave sleep.” This is thought to be the most important phase of sleep, during which much of the body’s rejuvenation and restoration takes place.
Secondly, marijuana reduces the amount of time spent in REM (“rapid eye movement”) sleep, which is the phase in which dreaming happens. This explains why many pot smokers can’t ever remember their dreams — they aren’t spending enough time in REM sleep to actually have an active dream life.
It also causes the “REM rebound” effect I mentioned earlier, where a smoker who quits experiences a sudden surge of intense and powerful dreams for several nights, or sometimes weeks.
Truthfully, there’s still a lot we don’t understand about the nature of sleep, what happens during the different stages, and why it’s so important; much less how the influence of cannabis on our sleep cycle might affect our mental and physical health in the long run.

Do the Benefits Outweigh the Risks?

Given the pros and cons, is marijuana really a good choice for those struggling with insomnia or other sleep disorders? To arrive at a fair answer to that question, let’s consider for a moment some of the most commonly prescribed alternatives — and the side effects associated with them.
(It’s worth mentioning here that trouble sleeping is usually just a sign of bigger problems, like depression or chronic anxiety — and cannabis may also help to treat these underlying issues.)
Some of the most common drugs prescribed as sleep aids are powerful “sedative hypnotics.” Examples include Ambien, Lunesta, Sonata, and sometimes Xanax, Klonopin, Ativan or Librium. These prescription pills are all potentially addictive or habit-forming, and in extreme cases have caused such effects as:

amnesia
hallucinations
sleep walking and sleep driving (wtf?!)
depression
abnormal behavior, sometimes violent
suicidal thoughts and actions

That’s some pretty heavy stuff. I mean, pot may suppress my dreams and make me feel kinda lousy in the morning, but it’s sure not gonna send me sleep-driving down the freeway at 70 mph. Or make me want to kill myself.
Okay, okay — so those are the most extreme cases; very rare. Fair enough. But even the most common side effects aren’t things I would wish on anybody. For instance:

drowsiness
dizzyness, loss of balance
trouble focusing or paying attention
memory loss
headache
heartburn
diarrhea
constipation
loss of appetite
tingling or burning in hands, legs and feet
uncontrollable tremors

When we consider the safety and effectiveness of marijuana as a medicine, we need to keep things in perspective… No, we don’t fully understand how pot affects the brain, or affects our sleep. But it’s a natural, herbal medicine that people have been smoking since the dawn of time. And the alternatives are dangerous synthetic chemicals that are known to cause serious harm, psychosis and even death.
For me at least, it’s an easy choice to make.

It’s All About the Strain

It’s also worth mentioning, as you probably already know, that there are some major differences in the way different kinds of bud affect you. It’s instructive (although really over-simplified) to differentiate between the two main strains of cannabis, namely indicas and sativas.
Indicas are shorter, bushier plants that are typically higher in THC. It’s commonly held (but not scientifically verified) that the indica high is more calming and relaxing, and the effects are felt primarily in the body.
Sativas plants are taller and ganglier, and tend to be higher in cannabidiol (CBD). The sativa high is generally much more energizing and cerebral (a mental, or “head high”).
It should be noted that after decades of careful cultivation and hybridization, there is now a dizzying variety of different strains, which combine the characteristics of both indicas and sativas in different ways. So there is really more of a colorful spectrum, as opposed to distinct categories.
The point is, that anyone wishing to use cannabis as a sleep aid is better off choosing an indica dominant strain, with a mellow, body high, instead of an uplifting and disorienting sativa strain.

Your Body, Your Choice

In the end, no one else can tell you how marijuana will affect you. Each person’s experience is unique, so you have to make an informed decision, and see for yourself how cannabis makes you feel, and what medicinal and psychological effects it has on you.
I think Dr. John Cline said it best:

“Cannabis is an exceedingly complex drug preparation, and its effects depend on the variety of the plant, the composition of the chemicals in any given sample, the route of administration, the setting in which it is used and the psychological state of the user.”