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Medical, ScienceMarch 23, 2017 by Adam Rhodes

Cancer Treatments: Now With Marijuana

Marijuana is an old remedy.

Modern cancer patients aren’t the only people to understand the healing power of marijuana. Marijuana is the name given to the cannabis plant during 20th century prohibition. Cannabis grows wild in warm and tropical climates throughout the world and has been cultivated commercially for eons. Prohibition has given cannabis many other aliases as people developed code. Names like pot, grass, cannabis, weed, hemp, hash, hydro, ganja, and dozens of others all describe the same plant.
Records show marijuana has been used in herbal remedies dating back to the Chin Dynasty in China. Ancient doctors could see the effects of using cannabis as well as today and prescribed it for many maladies. The herb was so powerful that even the Romans put it in their medical texts.
Scientists have identified many biologically active components in marijuana that are the main reason it is so useful medically. These compounds are called cannabinoids. The two most studied of the hundred or so cannabinoids are delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD). Other cannabinoids are being studied but haven’t had the same amount of press or research put into them.

Is marijuana a legal treatment?

At this time, the US Drug Enforcement Administration (DEA) lists marijuana and cannabinoids as Schedule I controlled substances that cannot legally be prescribed, possessed, or sold under federal law. Whole or crude marijuana (including marijuana oil or hemp oil) are also not approved by the US Food and Drug Administration (FDA) for medical use whatsoever.
State laws have a little bit more play in them and diverge from the federal stance to different degrees. The use of marijuana to treat some medical conditions is legal in many states even though it remains federally banned. Each state has individual rules about how they deal with marijuana so it is important to research the specific rules for your state.
Dronabinol (pharmaceutical THC) and some synthetic cannabinoid drugs like Marinol are approved by the FDA. Marinol is used to relieve nausea and vomiting for chemotherapy patients in addition to being prescribed to AIDS patients for appetite stimulation.

Marijuana is more than THC.

Different compounds found in marijuana have affect the human body in different ways. For example, delta-9-tetrahydrocannabinol (THC) causes the mental high and can also relieve pain and nausea. At the same time it can reduce inflammation and act as an antioxidant. Cannabidiol (CBD) can help treat seizures, can reduce anxiety and paranoia, and can counteract the “high” caused by THC according to the American Cancer Society.
Different cultivars (strains or types) of marijuana can have varying amounts of the different cannabinoids. The specific ratio of cannabinoids produced by a plant is known as it’s strain profile and can be used to better judge what effects to expect from a specific strain.
The effects of marijuana also change depending on how it enters the body:

When inactivated or raw cannabis is eaten, the THC is absorbed poorly by the body. Once absorbed, it’s processed by the liver into a second psychoactive compound. The second substance acts on the brain to change mood and/or consciousness differently than THC.
When marijuana is smoked or vaporized, THC enters the bloodstream quickly, bypassing the liver at first. It is transported to the brain before the liver can convert a large amount of it into the second chemical. Because there is so much less of the second chemical, the high is stronger but fades quicker.

What can marijuana treat?

A number of studies using small groups of marijuana users found that cannabis can be helpful for treating nausea and vomiting from cancer chemotherapy. A few studies have found that smoked or vaped cannabis can be helpful in the treatment of neuropathic pain as well.
Smoked marijuana has also helped improve food intake in certain HIV patients during some studies. Clinical trials have also been shown marijuana extract users tended to need less pain medication than others. The pain relieving effects seem to be even better in the non-psychoactive cannabinoid CBD than with THC.

How does marijuana affect cancer?

According to the American Cancer Society, “…THC and other cannabinoids such as CBD slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer.” While there have been some early clinical trials of cannabinoids in treating cancer, future studies are inevitable.
Most studies show cannabinoids can be safe in treating cancer. They do not however seem to help control or cure the disease. Relying on marijuana alone as treatment while avoiding or delaying conventional medical care for any issue (including cancer) may have serious health consequences.

What are the possible harms of marijuana?

While many insist marijuana can pose no harm to users, it is not true. The most common effect of marijuana is a feeling of euphoria. Yet the complex chemistry of the brain and cannabinoids indicates that there is a lot going on under the hood. Cannabis can lower the user’s control over movement, cause disorientation, and sometimes cause unpleasant thoughts or feelings of anxiety and paranoia. While the majority of users do not experience these negative effects, they are more common in new users who don’t understand their dosing requirements.
Smoked marijuana delivers THC and other cannabinoids to the body along with harmful substances. Tar is one of the substances found in both tobacco and cannabis smoke. Heavy users (more than one gram a day) of smoked cannabis also commonly report chronic bronchitis.

Make sure to do research.

Because marijuana plants come in different strains with different levels of active compounds, it can make each experience different. Even with good data from a state certified lab, the effects of a specific strain on a specific user can be very hard to predict. It can take time and experimentation to find the best treatment plan or strain for a specific issue.
Even though cannabis is not chemically addictive (like caffeine or an opioid) people can still become psychologically dependant. Users will not receive the life threatening withdraws like they do from cocaine but they may still feel the conditioned desire to use. Treatments and attitudes toward addiction vary widely across countries and the globe. If you struggle with addiction or are interested in treating any malady, it is best to seek a spectrum of qualified professional help before committing to any treatment plan. Make sure to get more than your own opinion before you make potentially life altering decisions. Thanks for reading.

Guides, Medical, ScienceFebruary 2, 2017 by Adam Rhodes

CBD: How Cannabidiol (CBD) is Natures Best Healing Compound

What is CBD?

Cannabidiol (CBD) is a naturally occurring compound found in cannabis plants.Scientific research over the last few decades has shown that Cannabidiol has dozens of medical benefits. Cannabidiol is one of over 60 compounds found in cannabis. Both THC and CBD belong to a class of molecules called cannabinoids.
Of the known cannabinoid compounds, CBD and THC are usually present in the highest concentrations, and are therefore the most recognized and studied. The difference between CBD and THC comes down to how they interact with the cannabinoid 1 (CB1) receptors. Cannabidiol inhibits the interaction of CB-1 receptors throughout the body with a major focus on receptors in the central nervous system.

How does CBD work in the body?

Cannabinoid receptors are cell membrane receptors that contain transmembrane spanning properties. Cannabinoid receptors are activated by three groups of ligands (a molecule that binds to another molecule): endocannabinoids that are produced inside the mammalian body, cannabinoids produced in plants and synthetic cannabinoids. Because CB-1 receptors bind with all three types of cannabinoids, one source can be supplemented for the other to provide medical benefit to patients.
The endocannabinoid system is a vast network of cell receptor proteins and serves many functions. CB-1 receptors are heavily concentrated in the central nervous system. Others types of cannabinoid receptors are found all over the body. They’re in every humans skin, digestive tract, and even in their reproductive organs. All of the endocannabinoids and plant cannabinoids bind to fatty compounds in the body. The binding properties of cannabinoids are why THC and CBD remain in a person’s system for so long.

How does CBD work in the brain?

Cannabidiol has low binding affinity for CB1 receptors. THC binds well with CB1 cannabinoid receptors but CBD does not. This is why one (THC) will cause a high and the other (CBD) will not. While this makes Cannabidiol a bad choice for recreational users, it is a significant advantage for use as a medicine. The high associated with cannabis is generally considered a side effect.
Since health professionals prefer treatments with minimal side effects. CBD is seen by most medical professionals as preferable to THC. CBD is non-psychoactive because it doesn’t act on the same pathways as THC. These pathways, called CB1 receptors, are highly concentrated in the brain and are responsible for the mind-altering effects of THC.

What does CBD do?

The fact that Cannabidiol-rich cannabis is non-psychoactive or less psychoactive than THC-dominant strains makes it an appealing option for patients who want to avoid the stereotypical feelings associated with consuming cannabis.
Scientific and clinical research underscores Cannabidiol’s potential as a treatment for a wide range of conditions. People looking for relief from inflammation, pain, anxiety, psychosis, seizures, and other conditions without disconcerting feelings of lethargy find Cannabidiol to be an effective treatment.
Conditions including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders find the most relief from treatments. This is because CBD has demonstrable neuroprotective and neurogenic effects along with anti-cancer properties. These properties are currently being investigated at several academic research centers around the world.

How does CBD treat all these health issues?

The biggest distinction between CBD vs. THC comes down to a basic difference in how each one interacts with cannabinoid 1 (CB1) receptors. THC binds well with CB1 cannabinoid receptors while CBD does not. Think of it like an electrical plug connecting to an outlet.
A THC molecule is perfectly sized to connect with CB1 receptors. When that connection happens, THC stimulates those CB1 receptors like turning on a switch. THC works to activate those CB1 receptors.Cannabidiol works in a different way. It doesn’t act directly to activate or suppress CB1 receptors. Instead, it acts to suppress the CB1-activating qualities of a cannabinoid like THC. So while THC turns on CB-1 receptors like sticking a key in an outlet, CBD blocks the outlet.

If CBD is so good, why isn’t it more mainstream?

Even though CBD shows great promise as a medicine, it remains illegal in most of the world. CBD is classified as a Schedule I drug (right beside THC) in the United States and a Schedule II drug in Canada and the UK.
The US government has been studying CBD for a while and fund most of the science going on stateside due to the difficulties associated in researching a schedule 1 substance. Even with the challenges, intrepid researchers have identified dozens of conditions that can be treated or cured using Cannabidiol.
A team of researchers at the California Pacific Medical Center, led by Dr. Sean McAllister, has stated that they hope to begin trials on CBD as a breast cancer therapy. Due to the challenges of navigating the FDA, they are fighting an uphill battle.

If CBD is great as medicine, why aren’t more drug companies using it?

All is not dark for CBD research. The U.S. Food and Drug Administration recently approved a request for a clinical trial of a CBD based drug. The drug in question is a pharmaceutical version of CBD used to treat children afflicted with rare forms of epilepsy. The drug is called Epidiolex and is made by GW Pharmaceuticals. GW Pharmaceuticals also makes another cannabis-based drug called Sativex.
Even with approval of trials for Cannabidiol based meds, the U.S. Drug Enforcement Agency (DEA) made it clear that marijuana-based extract is still considered a Schedule I drug under federal law. They made sure to say in a Dec. 2016 address that the ban includes CBD oils and other types of CBD-rich extracts.

What does the future of CBD look like?

In general, far more research is needed to figure out all of the effects cannabis has on our bodies. But, to say that our overall understanding of CBD is “lacking” would be an understatement. In the midst of medical and recreational legalization happening in the US state by state, the federal stance on cannabis remains staunchly opposed. While the UK classifies CBD as a schedule 2 substance, the US still tightly holds to its schedule 1 status of all things cannabis.
A pharmaceutical version of Cannabidiolwas recently developed by a drug company based in the UK. The UK based company, GW Pharmaceuticals, is now funding clinical trials on Cannabidiol as a treatment for schizophrenia and certain types of epilepsy through the significantly easier UK process.
Only time will tell if cannabis will become a mainstream medical tool in the future. With political pressure and overwhelming public support for legalization, there has been a lot of gains in recent years. As legislation moves cannabis out of the darkness and into the limelight, government agencies like the FDA will have to reevaluate how they have classified cannabis. Thanks for reading.

Analysis/Opinion, Guides, Medical, ScienceDecember 11, 2016 by Adam Rhodes

What Tetrahydrocannabinol or THC is used for

Dozens of years of research indicate many restorative uses for THC.

Tetrahydrocannabinol or THC, is often the most desired chemical found in cannabis. It is best known for bringing on the high that weed is known for. As one of the few compounds found in cannabis that is psychoactive, doctors and scientists have discovered many ways to utilize THC.
The extraction of pure Tetrahydrocannabinol was perfected by an Israeli physicist named Raphael Mechoulam. In 1964, Mechoulam separated and blended THC from Lebanese hashish, denoting the start of cannabis research that would prompt to the revelation of various different cannabinoids and how they interact with the body.
While the discoveries have been many and inspiring, they are not without their doubters. The federal government has classified cannabis as a schedule 1 drug meaning it has no medical benefit. This is in addition to the government obtaining patents for the neuro-protective capabilities of cannabis.
Be that as it may, while chemicals like cannabidiol (CBD) have begun to pick up support because of their absence of psychoactivity, many years of research have uncovered various health advantages one of a kind to THC. Here are a few of the most common uses.

Tetrahydrocannabinol relieves some types of pain.

A standout amongst the most common uses of therapeutic weed is for pain treatment. Upon closer examination, evidence has shown that Tetrahydrocannabinol interacts with the central nervous system to prevent the transmission of certain types of pain. Moreover, cannabis has been appeared to be particularly successful against neuropathic agony, or nerve-related pain.
The nerve signals that our brains sense as pain come from special cells with receptors on them. They become activated by temperature, touch, movement, or chemical changes in their environment. Pain signals arise and travel to the brain by one of three main pathways, each of which produces different pain sensations: somatic, visceral, and neuropathic.

There are three types of pain in general.

Somatic pain

is the feeling most people recognize when they think about pain: a message sent by receptors located throughout the body whenever injury occurs. Somatic pain signals travel to the brain through nerves bundles and are typically experienced as a constant, dull ache. THC is able to reduce swelling and other contributing factors to somatic pain but in general is not very effective treatment.

Visceral pain

occurs when skin or organs in the abdomen become stretched or otherwise disturbed from disease or injury. Pain signals issue from a special class of receptors present in the gut, producing feelings of pressure deep inside the body. Visceral pain can seem to be coming from different parts of the body than its actual source. THC is able to counteract feelings of nausea and many elements of chronic visceral pain.

Neuropathic pain

occurs when the nerves are injured. It is often experienced as a burning sensation that can occur in response to even a gentle touch. Neuropathic pain usually doesn’t respond to narcotic painkillers making it stand out from the other types of pain. Antidepressant or anticonvulsant drugs, along with surgical procedures normally treat this type of pain but THC has also been found to be highly effective.

Cannabis is an excellent plant that has shown surprisingly positive results as a neuropathic treatment. The Tetrahydrocannabinol within that cannabis is able to work on a level that crosses many typical treatment boundaries. Pain treated by THC may be acute or chronic, blindingly intense or mind-numbingly dull. The pain can be momentary or have persisted for days to years.
However long it takes before a patient tries cannabis, it doesn’t take long for them to finally find relief. For acute pain, such as the discomfort that follows surgery, doctors typically prescribe opiates: narcotic drugs derived from, or chemically similar to, opium.

THC is better at dealing with some types of pain than opiates.

During the short-term treatment of intense pain, opiates offer significantly stronger relief for most patients. For chronic pain however, the tables turn in favor of Tetrahydrocannabinol. Treating chronic pain with opiates rarely brings relief.
Chemical dependence also becomes an issue with opiates as usage continues. Cannabinoids like THC have been proven to be non-addictive and highly effective for chronic pain. These differences combine to show that cannabinoids have significant promise in neuroscience and fundamental understandings of pain.
Peripheral nerves that detect pain sensations contain abundant receptors. Many of these receptors are tailor made for cannabinoids. According to research, cannabinoids appear to block peripheral nerve pain in experimental animals. Even more encouraging, some initial studies suggest that opiates and cannabinoids suppress pain differently.
If that is the case, marijuana-based medicines could combine with opiates to boost pain-relieving power while limiting the side effects. There are real hurdles to overcome if the initial Tetrahydrocannabinol research holds up. With the exponential expansion of scientific frontiers in recent decades and the recent deregulation of cannabis in over 26 states, we should have a significantly better understanding in the next decade.

Some people even use Tetrahydrocannabinol to treat PTSD.

Post traumatic stress disorder has only recently been classified in the Diagnostic and Statistical Manual (DSM) compared to other psychosomatic issues. PTSD is tied to traumatic memories and affects people from every walk of life. Soldiers, doctors, librarians and children can all have PTSD. Finding a safe treatment for so many different demographics is almost impossible.
Discovery of the endocannabinoid system by Dr. Mechoulam made safe treatment of PTSD, along with Parkinson’s and Cerebral Palsy a possibility. Since its discovery in the 1950’s, science has learned that Tetrahydrocannabinol is pharmacologically plastic. By manipulating the endocannabinoid system with THC and other cannabinoids, doctors are able to offer relief to patients that would otherwise have none.

We need more research to discover all that THC has to offer.

With the federal government classifying cannabis as a schedule 1 narcotic, it makes research in America almost impossible. There are some states like Oregon, Washington, California and many others that have taken steps to end Tetrahydrocannabinol prohibition but the fight is far from over.
Scientists can’t study cannabis if government continues to demonize it. As more states join the green revolution, it puts pressure on federal legislators to rethink their stance on legalization. If the community is able to enact declassification of cannabis it will remove the final argument against full legalization.
Once cannabis is removed from the scheduled substance list, we will finally put the whole scientific community to work, not just one Israeli scientist. No disrespect to Isreal, it’s just that cannabis is grown in other places to. We shouldn’t be stopping the Jamaican, American or Ukrainian scientific communities from contributing to THC research.
Thanks for reading.

Analysis/Opinion, Guides, Medical, ScienceDecember 8, 2016 by Adam Rhodes

THC vs. CBD: What Do They Do?

Have you ever wondered what THC and CBD are?

For those who don’t know, tetrahydrocannabinol (THC) and cannabidiol (CBD) are potent chemical compounds produced in the trichomes on cannabis flowers. Trichomes are the small mushroom looking structures that sparkle like crystals in the light. Cannabis with a high concentration of THC or CBD is prized over just about anything else.
The states that allow cannabis sales require licensed retailers to prominently display the THC, CBD and possibly several other three letter words for everything with cannabis in it. People are always talking about how potent cannabis has become compared to times past and equating it with the THC and CBD content. This all points to THC and CBD being important, but why?
To start, cannabinoids are a group of compounds that our bodies and plants produce naturally. There are over 85 different cannabinoids identified so far with more just waiting to be catalogued. They are called cannabinoids because when Raphael Mechoulam first identified them back in 1964, they were in the cannabis plants the Israeli doctor was studying.
Science has shown that our own bodies produce and process cannabinoids in immune and nerve cells. Humans are not unique in this ability to process cannabinoids either. The systems needed can be found in many mammals including dogs and cats.
Some animals simply can’t process THC and CBD. Insects like bees and ladybugs don’t have the right systems to be affected by the cannabinoids produced in cannabis. So even if insects or reptiles get covered in cannabinoids, it can’t get them high.
Science is discovering that the connection humans have to cannabis goes down to the molecular level. Continued research into the structure of THC and CBD has revealed that they are structural isomers. Essentially, they have the same basic parts but get arranged in a different way.

How do THC and CBD Work?

Cannabinoids like THC and CBD are able to bond with a special network or system of receptors in our cells. This system is present in most mammals, that is why cats and dogs will respond to cannabis in similar ways as you and I.
The specific receptors responsible for how weed makes us feel are called the CB1 and CB2 receptors. They were named after the different cannabinoids they are specialized to work with. I agree it’s not a very interesting name but being as simple as possible makes for easier science.
This system is called the endo-cannabinoid system. Endo for inside and cannabinoid for the type of chemical they work with. Cannabinoids like THC and CBD activate the receptors by mimicking the neurotransmitters our bodies naturally produce called anandamides. Our bodies can’t tell the difference and accept the imposters without question. Yet each cannabinoid has a unique effect.

CB1 receptors respond to THC and are responsible for the psychoactive effects of cannabis. They are present in most of the brain and play a role in vital functions like; memory, mood, sleep, appetite and pain sensation. Cancer, insomnia, PSTD, MS, and many more disorders respond positively to CB1 stimulation.
CB2 receptors respond to CBD and are responsible for the anti-inflammatory effects of cannabis. They are found in immune cells and help reduce inflammation. Since inflammation is an immune response that is believed to be a factor in many diseases and conditions, controlling it can have life altering effects for people.

How are THC and CBD different?

THC is psychoactive, meaning it affects consciousness. Things like irritability, hunger and pain are all tied to brain function. THC reduces activity in the hippocampus, the part of the brain where memories are formed/stored). It also inhibits the amygdale, the part where the fight or flight instinct is stored/triggered.
If enough THC is added to the hippocampus, it can lead to a build-up of anxiety. Feelings of paranoia often accompany this negative reaction as the brain tries to deal with the elevated levels of cannabinoids. While no deaths have ever been recorded from weed alone, consuming cannabis does lead to reduced activity in certain parts of the brain.
While reducing brain activity is normally a bad thing, trauma and chemical imbalances can lead to hyperactivity in these brain areas. Conditions like PTSD and anxiety are examples where THC is one of the best treatments available. In fact, the VA recently made strides toward incorporating treatments into the framework of our military.
CBD is a totally different beast. It’s non-psychoactive, meaning it doesn’t affect consciousness directly. Yet it has been shown to have many beneficial properties. Things like swelling, decreased blood flow and seizures are all treatable by CBD.
Besides calming muscle spasms, CBD is able to counteract the psychoactive elements of THC. They have a balancing duality and because of their chemical similarities, it only takes a little acid to transition from THC to CBD and back again. Several companies have successfully synthesized cannabinoids already but it appears that the best effects come from natural plant sources.

How do we use THC and CBD?

Given that our bodies are hard-wired to benefit from cannabinoids, how do we get more? The oldest and most reliable way is to smoke some of the cannabinoid-rich trichomes that cover the cannabis flower. Vaporizing, eating and creating topical creams are also common ways to consume cannabinoids.
Modern extraction techniques exist that can produce almost 100% pure THC from raw plant matter. While this is the most potent/efficient way to consume THC, most commercial products range from 60-80%. Part of the reason lower percentage extracts are more common is the high cost of extremely pure THC or CBD comparatively.
Most people today consume cannabis in the form of food or concentrate to treat a malady or illness. Research has shown THC from smoking weed to be a neural-protector and helps slow/prevent Alzheimer’s. Cannabis can also provide relief to people suffering from neural conditions like Parkinson’s and Cerebral palsy. Patients often find more relief from their tremors, seizures and chronic pain than through other treatments.
Cannabinoids also play a part in the success of traditional cancer treatments like chemo therapy by stimulating appetite, relieving depression and reducing pain. While these benefits may seem minor, the increase in quality of life to these patients is measurable. Over time, the body will adapt to elevated cannabinoid levels so monitoring dosing is important.
Higher concentrations of THC and CBD are often needed for treatment of life threatening illness than can be found in raw cannabis. Over the centuries, this problem has been solved by refining the raw flower into concentrates. Products like BHO, PHO, RSO and CO2 extracts are excellent sources of concentrated THC to modern consumers.
Thanks for reading.

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