Marijuana doesn’t have a high potential for abuse

[Marijuana] doesn’t have a high potential for abuse, and there are very legitimate medical applications. In fact, sometimes marijuana is the only thing that works. Dr. Sanjay Gupta

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  • This is why cannabis is extremely safe…

    “Advantageously however, CB1 receptors are absent in the medulla oblongata, the part of the brain stem responsible for autonomic respiratory and cardiovascular function. This is highly advantageous when cannabinoids are used for and as sedative and anesthetic formulations. Affecting or depressing autonomic respiratory and/or cardiovascular function has long been a limiting disadvantage of known sedative and anesthetic formulations. Fortunately, unless introduced at extremely toxic levels, CB1 agonist cannabinoids primarily leave autonomic respiratory and cardiovascular functions in humans and animals unaffected, due to the lack of CB1 receptors in the brain stem medulla oblongata.”

    “CB1 receptors are predominantly found in the brain in the basal ganglia and the hippocampus. They are also found in the cerebellum, and the male and female reproductive organs. The CB1 receptor is associated with feelings of euphoria, and it also has plays a role in anticonvulsive pathways. The places where these receptors are absent are the medulla oblongata and the brain stem. The brainstem and medulla oblongata are responsible for cardiovascular and respiratory functions; not having the cannabinoid receptor would leave them completely unaffected by THC, or any other cannabinoid. The lack of cannabinoid receptors on the medulla also might suggest why there has never been a case of overdose of THC, regardless of the amount consumed or the method of consumption. Likewise, there is a lack of cannabinoid receptors on the mesocorticolimbic pathway means that there is a significantly decreased chance of physical addiction because a dopaminergic pathway is not involved.”

    https://www.linkedin.com/pulse/patented-cannabinoid-formulation-sedation-human-charles-ankner-cp?trk=mp-reader-card

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